But while the former Barcelona star has collected plenty of individual accolades, Messi and Inter Miami are still chasing the MLS’ top prize – the MLS Cup.
After topping the table to win the 2024 Supporters’ Shield, the franchise, part-owned by David Beckham and coached by Javier Mascherano, came up short in the play-offs.
Inter Miami had to settle for third in the standings this season but made a winning start to their play-off campaign in game one of their first-round series.
Messi put them in front with a diving header in the 19th minute after a floated cross from ex-Liverpool striker Luis Suarez.
Tadeo Allende doubled the lead in the second half before Messi bundled the ball home from close range to make sure of the win in stoppage time.
Nashville pulled one back through Hany Mukhtar in the 11th minute of added time but Inter Miami take a 1-0 series lead into game two in Nashville on 1 November.
The series winners will progress to the Conference semi-finals, from which point just one match will decide who advances.
The MLS Cup final is also a one-off game.