The Revolution schedule for the rest of the season opened up as they were unable to protect a lead three separate times and lost, 4-3, to Orlando City in the US Open Cup round of 16 contest in Pawtucket, R.I., on Wednesday night.
The loss ends a six-game unbeaten across all competitions (4-0-2) in a busy April that featured seven games.
Zakaria Taifi had a step on his defender to finish off a low cross from Tyrese Spicer two minutes into stoppage time to give Orlando City its first lead of the game.
New England conceded the tying goal in stoppage time in its previous US Open Cup game before advancing on penalty kicks.
The Revolution sat their regulars coming off Saturday’s 1-1 tie at Inter Miami, while Orlando made just four changes from a 3-2 loss at D.C. United.
Groton native Malcolm Fry opened the scoring for New England in the 21st minute, receiving a pass from Eric Klein and scoring from a tight angle along the left endline. Orlando countered 10 minutes later off a header into the top right corner from Teodoro da Silva Nogueira.
Andrew Farrell put the Revolution back in front in the 37th with his first goal since August 2018. Griffin Dorsey provided an answer for Orlando just two minutes later, ripping a shot past Revolution goalkeeper Donovan Parisian into the top right corner after a nice give-and-go with Justin Ellis after a cross from Iván Angulo.
New England nearly reclaimed the lead before halftime, but Tanner Beason hit the post.
Marcos Zambrano scored his first goal with the Revolution in the 58th minute, giving New England a 3-2 lead. But Orlando tied it for a third time when Parisian was unable to cleanly handle a Spicer cross from the left side, the ball spilling straight into the path of Ellis.
The Revolution resume the regular season with a four-game homestand Saturday night, hosting Charlotte.
Keith Pearson can be reached at keith.pearson@globe.com.