Inter Miami hosts Orlando City at the Nu Stadium this weekend as both teams look to improve their standing in the Eastern Conference.

Miami currently holds second place in the table but is searching for its first league victory at its new home after three consecutive draws there.

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Meanwhile Orlando City is struggling near the bottom of the conference and has conceded a league-high 29 goals so far this MLS season.

Inter Miami vs Orlando City Expected Lineups

Inter Miami is dealing with several key absences. Sergio Reguilon, David Ayala, and Mateo Silvetti are all unavailable for selection due to injuries.

Nicolas Freire and Facundo Farias also remain out of action as they continue their recovery from long-term ACL injuries.

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These absences will force some adjustments in the defensive and midfield rotations for the home side.

<a class="link " href="https://sports.yahoo.com/soccer/players/415357/" data-i13n="sec:content-canvas;subsec:anchor_text;elm:context_link" data-ylk="slk:Rodrigo De Paul;sec:content-canvas;subsec:anchor_text;elm:context_link;itc:0" data-yga="{"yLinkElement":"context_link","yModuleName":"content-canvas","yLinkText":"Rodrigo De Paul","ySubModuleName":"anchor_text","yHasCommerce":false}">Rodrigo De Paul</a> #7 of Inter Miami CF celebrates with teammate <a class="link " href="https://sports.yahoo.com/soccer/players/372884/" data-i13n="sec:content-canvas;subsec:anchor_text;elm:context_link" data-ylk="slk:Lionel Messi;sec:content-canvas;subsec:anchor_text;elm:context_link;itc:0" data-yga="{"yLinkElement":"context_link","yModuleName":"content-canvas","yLinkText":"Lionel Messi","ySubModuleName":"anchor_text","yHasCommerce":false}">Lionel Messi</a> #10 after scoring the team's first goal during the MLS match between <a class="link " href="https://sports.yahoo.com/soccer/teams/salt-lake/" data-i13n="sec:content-canvas;subsec:anchor_text;elm:context_link" data-ylk="slk:Real Salt Lake;sec:content-canvas;subsec:anchor_text;elm:context_link;itc:0" data-yga="{"yLinkElement":"context_link","yModuleName":"content-canvas","yLinkText":"Real Salt Lake","ySubModuleName":"anchor_text","yHasCommerce":false}">Real Salt Lake</a> and Inter Miami CF.Photo by Chris Gardner&sol;Getty ImagesRodrigo De Paul #7 of Inter Miami CF celebrates with teammate Lionel Messi #10 after scoring the team’s first goal during the MLS match between Real Salt Lake and Inter Miami CF.Photo by Chris Gardner&sol;Getty Images

Orlando City also has a significant list of players missing for this fixture. Forward Duncan McGuire is out, along with Joran Gerbet and Ivan Angulo.

The team is also missing Pedro Gallese, Wilder Cartagena, and Facundo Torres, which leaves the squad thin in both the goalkeeping and attacking departments.

Inter Miami:

Defenders: Micael, Falcon, Fray

Midfielders: Allende, Morales, De Paul, Mura, Messi, Segovia

Orlando City:

Defenders: Dorsey, Teodoro, Jansson, Marin

Midfielders: Cartagena, B. Ojeda; Otavio, Spicer

Inter Miami vs Orlando City Head-to-Head Stats

Head-to-Head Stats The rivalry between these two Florida clubs is closely contested. In 19 total meetings, Orlando City has a slight edge with 8 wins compared to 7 for Inter Miami, while 4 matches ended in a draw. However, Miami has performed better recently, winning the last two encounters by a combined score of 7-3.

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Inter Miami vs Orlando City Prediction

Most experts expect a high-scoring game due to Miami’s attacking threat and Orlando’s recent defensive issues.

We predict a 3-0 win for Inter Miami, considering Messi’s strong historical record against Orlando.

This story was originally published by Athlon Sports on May 2, 2026, where it first appeared in the Soccer section. Add Athlon Sports as a Preferred Source by clicking here.