PORT ST. LUCIE, Fla. (CBS12) — A road rage confrontation erupted into a violent four-vehicle crash on U.S. 1 Wednesday, leaving four injured and a Port St. Lucie man behind bars.

Officers with the Port St. Lucie Police Department say they responded around 6:45 p.m. to the intersection of South U.S. Highway 1 and SE Lyngate Drive/SE Tiffany Avenue, where investigators determined that a red Harley-Davidson motorcycle and a black Ford Super Duty pickup truck were involved in an ongoing road-rage incident.

Detectives say the pickup, driven by 54-year-old Kevin Lonergan, was pursuing the motorcycle as both vehicles traveled northbound on U.S. 1 and approached the intersection.

A road rage confrontation erupted into a violent four-vehicle crash on U.S. 1 Wednesday, leaving four injured and a Port St. Lucie man behind bars. (PSLPD)

A road rage confrontation erupted into a violent four-vehicle crash on U.S. 1 Wednesday, leaving four injured and a Port St. Lucie man behind bars. (PSLPD)

According to witness statements and dash-camera video, the motorcycle entered the intersection against a red light and collided with a black Chevrolet Silverado, throwing the 31-year-old rider from the bike.

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Police say Lonergan then entered the intersection against the red signal, struck the ejected motorcyclist, and crashed head-on into a blue Toyota RAV4.

The motorcyclist and two people inside the RAV4 were taken to Lawnwood Medical Center, per PSLPD. The Silverado driver was transported to St. Lucie Medical Center.

Investigators say the motorcyclist suffered serious injuries, including a brain bleed and facial fractures, and lost consciousness after the crash. He remains hospitalized in stable condition.

Based on witness statements, dash-camera video and the investigation, police arrested Lonergan for two counts of reckless driving causing serious bodily injury and one count of reckless driving causing injury.

After being medically cleared, Lonergan was booked into the St. Lucie County Jail.

The intersection remained closed for hours while investigators processed the scene before all lanes reopened around 2 a.m. Thursday.