Two people were killed after deadly Hurricane Isaias hit the southeast “like a freight train” with walloping 105 mph winds.

The victims died in separate tragedies when trees fell on their homes in Escambia County, Florida, and Birmingham, Alabama.

“The storm is here. Buckle down at this point. Don’t be getting out on the roads,” Florida Gov. Ron DeSantis said at a news conference, warning that flash flooding would be a hazard “throughout the region.”

Florida Lt. Gov. Jay Collins gives an update as the state is hit by Hurricane Isaias on Oct. 9, 2026. Fox News

“This is going to be a panhandle-wide event … We’re ready for it, and we just got to get through it.”

The storm was expected to reach Hurricane 3 status — but weakened before it came ashore and by early Saturday was no longer considered a hurricane as its wind speeds continued to decrease.

Palm trees blow in the wind as floodwaters submerge a road during Hurricane Isaias in Destin, Fla., Friday, Oct. 9, 2020.

But it still wrought destruction across the southeast, with downed trees killing residents and water flooding many neighborhoods.

One woman in Escambia County, Florida, died late Friday when a tree smashed into her home, Sheriff Chip Simmons said.

Palm trees blow in the wind as severe flash flooding lashes Destin, Fla., on Friday, Oct. 9, as Hurricane Isaias approaches.

Another person was killed in Alabama after a tree fell onto a Birmingham home early Saturday, Jefferson County Emergency Management Agency Director Jim Coker told the Tuscaloosa News.

In Dale County, Alabama, a sheriff’s deputy was injured when a tree fell on him while responding to a car accident.

Both Destin and Fort Walton Beach were under an extreme wind warning and flash flood emergency warning.

Sheriff Mason Bynum told News4 the deputy was responding to a rollover crash when a tree fell on one of the vehicles involved, trapping the driver and striking the deputy.

The driver was unharmed, but the deputy was taken to a local hospital with minor injuries, Bynum says.

More than 664,000 customers in Florida and Alabama were without power early Saturday, according to poweroutage.com.

Shocking footage from the Sunshine State showed water gushing down driveways and flooding the shores.

Palm trees blow in strong winds and floodwaters rise in Destin, Fla., as Hurricane Isaias approaches Friday, Oct. 9, in footage filmed by Clint Hendricks IV.

Roughly 900,000 people had heeded the warnings to leave Isaias’ path before it made landfall with 105 mph winds near Destin, Fla., around 9:30 p.m. ET on Friday.

“This thing hit like a freight train. It was fast. It came in like a Mike Tyson punch,” Lt. Gov. Jay Collins told Fox News on Friday. “It’s real, I’m sure there is going to be real damage.”

“While some might have ridden it out, if you have please hunker down, stay safe, let’s not put our first responders at risk and they’ll get to you as soon as humanly possible, but let’s let them do their job and remain safe as well,” he warned.

But AccuWeather meteorologist Dan DePodwin told The Post, “The worst of the impacts are done.”

A fence begins to topple over as Hurricane winds and rain strike Florida’s Panhandle. Clint Hendricks IV via Storyful

Roughly a foot of rain was dumped in many places Friday, DePodwin said.

Showers were still expected throughout the panhandle Saturday, especially in North Carolina and Tennessee Valley — and even tornadoes in some spots.

Palm trees are caught in strong gusts of wind as rain begins to flood the streets of Santa Rosa Beach. Clint Hendricks IV via Storyful

“The risk area today is about Tallahassee, Florida over to Jacksonville and north towards Charleston, South Carolina and Augusta, Georgia,” said DePodwin.

There will be scattered storms through the rest of the weekend with some areas getting as much as four inches of rain, according to the meteorologist.

That means flash flooding is still a risk, he warned, especially in the Carolinas.

“The main message is most places have good weather for recovery efforts starting today but still be some heavy downpours that cause ponding on our roadways and such and can be a spin up tor,” he said.

With Post wires