The Miami RedHawks (5-5, 4-2 MAC) and Buffalo Bulls (5-5, 4-2) meet Wednesday night at UB Stadium in Buffalo, New York. The midweek Mid-American Conference tilt is ticketed for a 7 p.m. ET (ESPN2) opening kickoff. Let’s analyze BetMGM Sportsbook’s NCAA football odds around the Miami (Ohio) vs. Buffalo odds and make our expert college football picks and predictions for the best bets.

Miami is playing in its third straight weeknight game. Last Wednesday, the +5.5 RedHawks lost 24-3 to the Toledo Rockets (Under 44.5). QB DeQuan Finn did not play and has since left the program to begin preparing for the NFL. Miami was hampered by 3 interceptions and registered just 222 total yards against Toledo.

Buffalo also played last Wednesday. The +2.5 Bulls coughed up a season-high in points in a 38-19 (Over 44.5) loss at Central Michigan.

The teams have alternated wins over their last 6 meetings with the last of those being in 2023, a 23-10 win by Miami, which leads the all-time series 17-9.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

Watch NCAA football on Fubo!Miami at Buffalo odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 7:12 p.m. ET.

Moneyline (ML): Miami -115 (bet $115 to win $100) | Buffalo -105 (bet $105 to win $100)Against the spread (ATS): Miami -1.5 (-105) | Buffalo +1.5 (-115)Over/Under (O/U): 39.5 (O: -115 | U: -105)Miami at Buffalo picks and predictionsPrediction

Miami 23, Buffalo 20

No interest; PASS.

Miami is 5-2 ATS over its last 7 games. Buffalo is 1-6-1 ATS over its last 8.

The Miami defense-and-special-teams combo stands out in this matchup. Buffalo has struggled on offense, has turned the ball over 11 times in its last 3 games, and is up against a Miami defense which does well to cause havoc. And if the RedHawks can gain a 2-score advantage, the Buffalo passing game vs. Miami pass defense is a major advantage sector for the visitors.

QB Henry Hesson and Miami’s offensive staff have now had the time to move a Finn-less Redhawks offense forward. Hesson went 11-of-38 with 3 picks against Toledo. But the Rockets defense is a couple of notches tougher than Buffalo’s.

MIAMI -1.5 (-105) is worth a partial-unit look in this Wednesday night game.

UB’s last 20 games have seen the Over go 13-7.

Tab this matchup as one ripe for some turnover-fueled, short-field exchange. Peg expectations for these offense being a tad too low, and on a chilled, but otherwise benign, weather evening in Buffalo, the OVER 39.5 (-115) is the value side.

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