Colts at Jaguars odds, picks and predictions

Dec. 6, 2025, 1:38 p.m. ET

The Indianapolis Colts (8-4) and Jacksonville Jaguars (8-4) meet Sunday at EverBank Stadium in Jacksonville, Florida. Kickoff is set for 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Colts vs. Jaguars odds and make our expert NFL picks and predictions for the best bets.

The Colts lost to the Houston Texans 20-16 Sunday in Week 13 action, failing to cover as a 3-point home favorite. The Under (44) cashed. QB Daniel Jones ended with 201 passing yards and 2 touchdowns on just 14 completions. Indianapolis, after a 7-1 start to the season, has lost 3 of its last 4 games and has gone 1-2-1 against the spread (ATS) in that span. It is 7-4-1 ATS on the season.

The Jaguars throttled the Tennessee Titans 25-3 Sunday, covering with ease as a 6-point road favorite. The Under (42) hit. Without a rusher going over 30 yards, QB Trevor Lawrence did most of the damage, ending with 229 yards and 2 touchdowns. Jacksonville has rattled off 3 straight wins, covering in each of those. They are also 7-4-1 ATS on the season.

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Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1:20 p.m. ET.

Moneyline (ML): Colts -130 (bet $130 to win $100) | Jaguars +110 (bet $100 to win $110)Against the spread (ATS): Colts -1.5 (-110) | Jaguars -1.5 (-110)Over/Under (O/U): 46.5 (O: -115 | U: -105)Colts at Jaguars key injuries

Colts

CB Sauce Gardner (calf) outDE Tyquan Lewis (ankle) questionable

Jaguars

DT Arik Armstead (hand) questionableOT Walker Little (concussion) outDE Travon Walker (knee) questionableWR Parker Washington (hip) questionableS Andrew Wingard (concussion) outColts at Jaguars picks and predictionsPrediction

Jaguars 27, Colts 18

BET JAGUARS (+110).

The availability of Walker and Armstead will be crucial for Jacksonville, but it is 4-2 straight up at home and has allowed 20 or fewer points in 4 of those contests. The Jaguars’ defense has been on fire, limiting their last 3 opponents to a combined 33 points.

The Colts have hit a rough patch, especially offensively. They have tallied 20 or fewer points in 3 of their last 6 games and have lost 2 in a row on the road. This is certainly attributable to Jones playing with a fibula fracture. Considering those trends, back the home side to come out on top and take JAGUARS (+110).

PASS.

While the spread could have some value, the preferred route given these odds is on the moneyline. Both teams combined have had just 1 game end with a single-point margin.

BET UNDER 46.5 (-105).

Both teams are 6-6 O/U on the season, and each is slightly trending towards the Under. The Jaguars are 1-2 O/U in their last 3 games and have gone 0-3 O/U across their last 3 home contests.

The Colts are 1-3 O/U in their last 4 home games. Their offense has been a major cause of concern, while their defense has yet to allow more than 28 points in a single game.

Take UNDER 46.5 (-105).

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Colts at Jaguars odds, picks and predictions

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