Jaguars at Colts odds, picks and predictions

Dec. 27, 2025, 6:57 p.m. ET

The Jacksonville Jaguars (11-4) and the Indianapolis Colts (8-7) meet Sunday in Week 17 at Lucas Oil Stadium in Indianapolis, Indiana. Kickoff is set for 1 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s NFL odds around the Jaguars vs. Colts odds and make our expert NFL picks and predictions for the best bets.

The Jaguars extended their winning streak to 6 games in Week 16 with a 34-20 road victory over the Denver Broncos. Jacksonville won outright as a 3.5-point underdog with the Over (46) cashing. QB Trevor Lawrence threw for 279 yards and 3 TDs, adding a rushing score. WR Parker Washington had in 6 catches for 145 yards and a TD. The win snapped Denver’s 12-game home winning streak.

The Colts’ skid reached 5 games in Week 16 with a 48-27 loss to the San Francisco 49ers on Monday night. Indianapolis failed to cover as 3.5-point home underdogs as the Over (46.5) hit. QB Philip Rivers threw for 277 yards and 2 TDs to WR Alec Pierce, but 49ers LB Dee Winters had a 74-yard interception return on Rivers’ final throw.

The Jaguars beat their AFC South rivals 36-19 in Week 14 and have won 4 of the last 5 meetings, but the Colts lead the all-time series 28-21.

Watch the NFL on Fubo!Jaguars vs. Colts odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 6:49 p.m. ET.

Moneyline (ML): Jaguars -250 (bet $250 to win $100) | Colts +200 (bet $100 to win $200)Against the spread (ATS): Jaguars -5.5 (-110) | Colts +5.5 (-110)Over/Under (O/U): 48.5 (O: -110 | U: -110)Jaguars vs. Colts key injuries

Jaguars

CB Jourdan Lewis (foot) outLB Jalen McLeod (ankle) outRG Patrick Mekari (back) outDE Danny Striggow (ankle) outRB Bhayshul Tuten (finger) questionable

Colts

C Tanor Bortolini (concussion) outDT DeForest Buckner (neck) outWR Ashton Dulin (hamstring) questionableCB Sauce Gardner (calf) questionableRB Tyler Goodson (ankle) questionableLB Buddy Johnson (illness) questionableTE Andrew Ogletree (neck) outLT Bernhard Raimann (elbow) questionableS Daniel Scott (knee) outRG Dalton Tucker (shoulder) questionableDE JT Tuimoloau (oblique) outJaguars vs. Colts picks and predictionsPrediction

Jaguars 34, Colts 20

PASS.

I’ve got Jacksonville (-250) handling its business on the road, but not at these odds. I’ll take my wager to the spread.

BET JAGUARS -5.5 (-110).

The Jaguars re absolutely rolling, and the confidence showed up loud and clear in that win at Denver. Lawrence is playing the best football of his career right now, stacking big games without putting the ball in harm’s way. When a quarterback is this hot, I’m not looking to step in front of it.

The Colts, on the other hand, are trending the wrong way. Giving up 48 points to San Francisco with extra prep time is a massive red flag, and it’s hard to trust that defense to suddenly tighten up. Rivers has been fine in his return, but asking him to keep pace with this Jaguars offense feels like a stretch.

Jacksonville has scored at least 34 points in 3 straight games and already handled Indianapolis by double digits earlier this month. The Jaguars are also one of the best ATS teams in the league (10-5), and this number stays short because of the division angle. I don’t need to overthink it. Lawrence is locked in, Jacksonville is confident, and the Colts can’t stop anyone right now. I’ll take the Jaguars to get it done again.

BET OVER 48.5 (-110).

The Over has cashed in the last 6 meetings between these teams. Jacksonville has gone Over in 3 of its last 4 games and is averaging 34.1 points during its 6-game winning streak. Indianapolis has hit the Over in 6 of its last 10 games and is allowing 34 points per game over its last 3 outings.

WIN YOUR FANTASY FOOTBALL LEAGUE! The Huddle has been turning players like you into winners for over 25 years. This season, it’s your turn. Custom fantasy football rankings, sleepers and tools are just a click away. Subscribe now!

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow SportsbookWire on Twitter/X and like us on Facebook.

Access more NFL coverage:

Gambling involves risk. Please only gamble with funds that you can comfortably afford to lose.  While we do our utmost to offer good advice and information we cannot be held responsible for any loss that may be incurred as a result of gambling.  We do our best to make sure all the information that we provide on this site is correct. However, from time to time mistakes will be made and we will not be held liable. Please check any stats or information if you are unsure how accurate they are. No guarantees are made with regards to results or financial gain. All forms of betting carry financial risk and it is up to the individual to make bets with or without the assistance of information provided on this site and we cannot be held responsible for any loss that may be incurred as a result of following the betting tips provided on this site.  Past performances do not guarantee success in the future and betting odds fluctuate from one minute to the next. The material contained on this site is intended to inform, entertain and educate the reader and in no way represents an inducement to gamble legally or illegally or any sort of professional advice.

Gannett may earn revenue from sports betting operators for audience referrals to betting services. Sports betting operators have no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. Terms apply, see operator site for Terms and Conditions. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24/7 at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800-9-WITH-IT (IN). Must be 21 or older to gamble. Sports betting and gambling are not legal in all locations. Be sure to comply with laws applicable where you reside. It is your sole responsibility to act in accordance with your local laws.

Jaguars at Colts odds, picks and predictions

Tags: