The Buffalo Bills travel to Jacksonville this Sunday for a high-stakes AFC Wild Card clash against the Jaguars at EverBank Stadium. While the 12-5 Bills have reached the postseason for the seventh consecutive year, they arrive as the No. 6 seed after their division dominance finally slipped. Buffalo received a major boost this week as Josh Allen was a full participant in practice, signaling his injured foot is healthy enough for the playoff opener.

The Jaguars (13-4) enter as AFC South champions and one of the league’s hottest teams, riding an eight-game winning streak. Jacksonville features a defense that ranks second in the NFL in interceptions, posing a significant threat to a Buffalo offense that has leaned heavily on rushing champion James Cook lately. This matchup between two of the AFC’s elite scoring units has prompted analysts to perform a final reevaluation of Sunday’s projections.

The results of these simulations were compared to updated sportsbook odds to compile the data-driven Bills-Jaguars preview below.

Bills vs. Jaguars betting preview

Explore the interactive widget below to discover the current spread, total, and moneyline betting odds and probabilities for the Bills-Jaguars matchup at EverBank Stadium.

This prediction and best bet for Sunday’s NFL matchup between the Bills and Jaguars is from Dimers.com, a leader in sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

Key information on the Bills vs. Jaguars matchup, including where the game is and what time it kicks off.

Teams: Buffalo Bills vs. Jacksonville JaguarsDate: Sunday, January 11, 2026Kickoff: 1 p.m. ESTLocation: EverBank StadiumNFL standings: Current NFL division standingsNFL injuries: Check the latest updates to the official NFL injury reportOdds

The latest and best odds for the NFL battle between the Bills and Jaguars.

Spread: Bills -1 (-102), Jaguars +1 (-118)Moneyline: Bills -108, Jaguars -108Total: Over/Under 51.5 (-112/-105)

The odds and lines featured here are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Bills vs. Jaguars

Using trusted data analysis and computer power, the experts at Dimers have performed 10,000 simulations of Sunday’s Bills vs. Jaguars matchup.

According to Dimers’ renowned predictive analytics model, the Bills are more likely to beat the Jaguars at EverBank Stadium. This prediction is based on the model giving the Bills a 55% chance of winning the game.

Elsewhere on the betting board, Dimers predicts that the Bills (-1) have a 52% chance of covering the spread, while the 51.5-point over/under has a 54% chance of staying under.

These predictions and probabilities are correct at the time of publication but are subject to change.

Bills vs. Jaguars best bet

Our top pick for the Bills vs. Jaguars game on Sunday is to bet on Under 51.5 points (-105).

This betting advice is based on detailed modeling and valuable wagering intelligence, designed to assist you in making smarter investments.

Score prediction for Bills vs. Jaguars

Dimers’ projected final score for the Buffalo vs. Jacksonville game on Sunday has the Bills winning 25-24.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

NFL player props: Sunday

NFL props are an exciting way to wager on Sunday’s game without necessarily betting on its outcome.

This article features the most likely first and anytime touchdown scorers for the Bills and Jaguars, along with projected player stats.

Buffalo BillsFirst touchdown scorer predictionsJames Cook: 11.3% probabilityJosh Allen: 9.7% probabilityKhalil Shakir: 4.2% probabilityAnytime touchdown predictionsJames Cook: 56.2% probabilityJosh Allen: 50.5% probabilityKhalil Shakir: 26.1% probabilityProjected box score leadersQB passing yards: Josh Allen, 234 yardsReceiving yards: Khalil Shakir, 48 yardsRushing yards: James Cook, 87 yardsJacksonville JaguarsFirst touchdown scorer predictionsTravis Etienne: 12.3% probabilityTrevor Lawrence: 6.7% probabilityParker Washington: 5.7% probabilityAnytime touchdown predictionsTravis Etienne: 53.2% probabilityTrevor Lawrence: 34.0% probabilityParker Washington: 29.8% probabilityProjected box score leadersQB passing yards: Trevor Lawrence, 245 yardsReceiving yards: Jakobi Meyers, 57 yardsRushing yards: Travis Etienne, 65 yardsNFL Week 19: Bills vs. Jaguars

Get ready for Sunday’s matchup between the Bills and Jaguars in the Wild Card Round of the NFL season at EverBank Stadium, which is scheduled to start at 1 p.m. EST. We emphasize that all of the NFL predictions and NFL best bets in this preview are based on 10,000 data-driven simulations of the Bills vs. Jaguars matchup, and they are correct at the time of publication. They are intended to assist you make more informed choices when placing bets at online sportsbooks.

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