The final game of this MLS weekend is Inter Miami hosting San Diego FC at Nu Stadium in Miami, Florida.

Inter Miami is 3rd in the Eastern Conference with 45 points after 25 league games played, and San Diego FC is 10th with 30 points after 25 league matches played.

San Diego FC are winless in their last three matches, losing three consecutive league matches in the MLS.

Inter Miami drew 2-2 with Nashville SC last weekend in the MLS, but during the week, the Herons played in the Campeones Cup Final against Liga MX champions Cruz Azul. Inter Miami defeated Cruz Azul 2-0 with goals from Lionel Messi and Casemiro.

 Inter Miami’s Argentine forward #10 Lionel Messi holds up the trophy with teammates after his team defeated Mexico’s Cruz Azul in the Campeones Cup final at Nu Stadium in Miami, Florida, on September 16, 2026. (Photo by CHANDAN KHANNA / AFP via Getty Images) Photo by CHANDAN KHANNA / AFP via Getty Images Inter Miami’s Argentine forward #10 Lionel Messi holds up the trophy with teammates after his team defeated Mexico’s Cruz Azul in the Campeones Cup final at Nu Stadium in Miami, Florida, on September 16, 2026. (Photo by CHANDAN KHANNA / AFP via Getty Images) Photo by CHANDAN KHANNA / AFP via Getty Images

Lionel Messi scored a goal and provided an assist in the match against Cruz Azul. Messi has 13 goal contributions in eight straight games. For tonight’s match, Inter Miami will have Lionel Messi available and is expected to start with Luis Suarez up front.

Inter Miami will be without Tadeo Allende, Ian Fray, Telasco Segovia, and Mateo Silvetti due to injuries.

San Diego FC will be without Alex Mighten, Gabriel Pirani, and Amahl Pellegrino due to injuries. Oscar Verhoeven is unavailable today because he is suspended for yellow-card accumulation.

Expected Lineups for Inter Miami and San Diego FC

Inter Miami

Goalkeeper: Dayne St. ClairDefenders: Fricio Caicedo, Maximiliano Falcon, Casemiro, Facundo MuraMidfielders: Matias Galarza, Yannick Bright, Rodrigo De PaulForwards: German Berterame, Luis Suarez, Lionel Messi

San Diego FC

Goalkeeper: Duran FerreeDefenders: Kieran Sargeant, Ian Murphy, Manu Duah, Oscar VerhoevenMidfielders: Onni Valakari, Jeppe Tverskov, Alejandro AlvaradoForwards: Elias Achouri, Amahl Pellegrino, Anders Dreyer

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This story was originally published September 20, 2026 at 2:35 PM.