A pair of SEC heavyweight matchups highlight the slate of games to make Week 12 college football picks on with Alabama vs. Oklahoma and Texas vs. Georgia. These are four of the nine winningest FBS programs, all-time, and whatever college football bets you make on these contests may also come in handy if they meet again in the postseason. Meanwhile, the team they’re all looking up to in the CFP Rankings, No. 1 Ohio State, will have its first Big Ten matchup versus UCLA, with the Buckeyes favored by 31.5 points according to the Week 12 college football odds.

That matchup will see Nico Iamaleava face the team where his Tennessee tenure ended against, as the Vols fell to Ohio State in last year’s CFP. Is that extra incentive for the UCLA quarterback enough to back the Bruins with Week 12 college football predictions? Before locking in any Week 12 college football picks on those games or others, be sure to see the latest Week 12 college football predictions from SportsLine’s proven model. 

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The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of over $2,000 for $100 players on its top-rated college spread football picks. Anybody following its college football betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, it has turned its attention to the latest college football odds and Week 12 college football betting lines on the spread, money line, and over/under. Head here to see every pick. 

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Top college football predictions for Week 12

One of the college football picks the model is high on during Week 12: the 11th-ranked Oklahoma Sooners (+7, 45.5) cover versus No. 4 Alabama in a 3:30 p.m. ET Saturday kickoff. Oklahoma pulled off a road upset at Tennessee on Nov. 1 before having a bye last week, while Bama had a physical win over LSU on Saturday. One can’t discount the rest advantage that provides the Sooners as Alabama has covered in just one of its last five games when it has a rest disadvantage. OU quarterback John Mateer is undefeated (3-0) on the road with Oklahoma and has 17 total touchdowns versus just two interceptions over his last six road games overall. The model forecasts Oklahoma to go into Tuscaloosa, Ala., and cover over 50% of the time. See the rest of the model’s picks here.

Another prediction: No. 16 Miami (-14.5, 55.5) covers at home versus NC State on Saturday at 3:30 p.m. ET. Being at home is important to note for the Canes as NC State has lost both on the scoreboard and versus the spread in three straight road games. The Wolfpack’s defense will be the weakest unit on the field come Saturday as it’s allowed 41.7 points over its last three, while Miami’s defense is the strength of its team. The Hurricanes rank 10th in FBS by allowing just 15 points per game, and of their last six home games, they’ve allowed a lone touchdown — or no trips to the end zone at all — in five of them. The model has Miami covering well over 50% of the time, with the Over hitting in well over 60% of simulations in an A-rated pick. See which other picks the model likes here.

How to make college football picks for Week 12

The model has also made the call on who wins and covers in every FBS matchup in Week 12, and it’s calling for multiple upsets in major games, including a pair of ranked teams outright losing to unranked foes. You can only get every pick for every game at SportsLine, and for a limited time you can use promo code CHAMPIONSHIP to get your first month at SportsLine for $1.

So what college football picks can you make with confidence, and which ranked squads go down? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.

Week 12 college football odds for notable games

See full Week 12 college football picks, odds, predictions here

(odds subject to change)

Tuesday, Nov. 11

Kent State vs. Akron (-4.5, 47.5)

Ohio vs. Western Michigan (+1.5, 47.5)

Wednesday, Nov. 12

Buffalo vs. Central Michigan (-2.5, 43.5)

Toledo vs. Miami-OH (+3, 44.5)

Thursday, Nov. 13

Troy vs. Old Dominion (-10.5, 53.5)

Friday, Nov. 14

Clemson vs. Louisville (-3.5, 51.5)

Minnesota vs. Oregon (-22.5, 45.5)

Saturday, Nov. 15

Michigan vs. Northwestern (+10, 41.5)

Notre Dame vs. Pittsburgh (+10.5, 56.5)

UCF vs. Texas Tech (-23.5, 48.5)

NC State vs. Miami (-14.5, 55.5)

Iowa vs. USC (-6.5, 49.5)

Oklahoma vs. Alabama (-7, 45.5)

Texas vs. Georgia (-6.5, 48.5)

UCLA vs. Ohio State (-31.5, 48.5)