2.Big, big loss. The Jaguars’ dominant, 21-0 second quarter Sunday was marred by a significant injury, with nose tackle DaVon Hamilton sustaining a knee injury on a play that resulted in a key Colts fumble that led to a Jaguars touchdown. On the play, on which defensive end Bryan Thomas Jr. recovered the fumble at the 50-yard line, Hamilton’s knee buckled as he shed blocks. Hamilton, a seventh-year veteran who is critical to the Jaguars’ dominant run defense, left the field on a cart and was ruled out of the game soon thereafter. “He’s out there laying down and he’s reassuring me,” Coen said. “That’s who he is. He has a smile on his face, actually. He trusts God. He trusts himself. He trusts life. He’s just one of those types of people. It’s tough to see that, obviously. Really tough. We have to evaluate what it truly is.”