Spread<\/p>\n
Jaguars +2.5 (-102)Broncos -2.5 (-118)<\/p>\n
Moneyline<\/p>\n
Jaguars: +124Broncos: -148<\/p>\n
Total<\/p>\n
45.5 (Over -108\/Under -112)<\/p>\n
The Broncos remain 2.5-point favorites in this game \u2013 the same number they opened at<\/a> \u2013 despite the blowout loss to Kansas City in Week 1.\u00a0<\/p>\n Jacksonville put on a show on offense against Cleveland to open the season, but oddsmakers aren\u2019t ready to pronounce Denver\u2019s season over just yet. It\u2019s possible this line could move to Denver -3 by kickoff on Sunday.\u00a0<\/p>\n Jaguars vs. Broncos Score Prediction<\/p>\n Earlier this week, SI Betting\u2019s Iain MacMillan shared his favorite bet for this game in his Road to 272 column<\/a>, and he\u2019s taking the Jags to pull off an upset win:\u00a0<\/p>\n Heading into this season I was extremely high on the Jaguars and extremely low on the Broncos compared to the betting market, and Week 1 did nothing but reinforce my opinions on both teams so I see no reason why I shouldn’t bet the Jaguars to win this game outright on Sunday afternoon.<\/p>\n The Jaguars finished the week as the second-best team in the NFL according to DVOA, behind only the 49ers. Their defense was dominant and Trevor Lawrence looked extremely comfortable in his second year in Liam Coen’s system.<\/p>\n Meanwhile, Bo Nix and the Broncos offense has some work to do if they want to compete in the AFC this season.<\/p>\n I couldn\u2019t agree with MacMillan more after Denver\u2019s terrible showing in Week 1.\u00a0<\/p>\n The Broncos were the No. 1 team in defensive success rate and No. 7 in defensive EPA\/Play last season, but they struggled tackling in Week 1 against Kansas City, missing 28 tackles and allowing 247 yards after those misses.\u00a0<\/p>\n The Broncos defense missed 28 tackles against the Chiefs, allowing 247 yards after missed tackles, the most yards allowed by any defense in a game since at least 2018.<\/p>\n The Broncos had eight different defenders miss multiple tackles on the night.#DENvsKC<\/a> | #ChiefsKingdom<\/a><\/p>\n \u2014 Next Gen Stats (@NextGenStats) September 15, 2026<\/a><\/p>\n That\u2019s not going to cut it against any team, and I don\u2019t think things will get easier against Lawrence and the Jaguars, who put on an offensive clinic in Week 1 against the Cleveland Browns. Oh, and the Chargers beat Denver by two touchdowns in Week 16 during the 2025 season.\u00a0<\/p>\n Denver may be a tougher opponent than Cleveland, but it had the worst EPA\/Play on offense in Week 1 with Davis Webb calling the plays. I wouldn’t be shocked if Denver starts the season 0-2.\u00a0<\/p>\n Final Score Prediction: Jaguars 24, Broncos 16<\/p>\n Odds refresh periodically and are subject to change.<\/p>\n If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.<\/p>\n Claim the latest\u00a0DraftKings promo code<\/a>\u00a0offer today. Sign up and get\u00a0$150 in bonus bets instantly when you make your first $5 bet.<\/a><\/p>\n
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