Port St. Lucie had the fastest population growth among the largest cities in the United States in 2025, for the fifth consecutive year.<\/p>\n
MIAMI REALTORS\u00ae + RWorld, a realtor association, analyzed the U.S. Census Bureau’s Vintage 2025 population estimates<\/a> and found that Port St. Lucie was No. 1 among the 91 largest U. S. cities with populations of 250,000 or more.<\/p>\n From July 1, 2024 to July 1, 2025 Port St. Lucie’s population increased 3.5%, which is 9,131 people, according to MIAMI REALTORS\u00ae + RWorld.<\/p>\n The association also looked at the increase over the last five years. From July 2020 to July 2025 Port St. Lucie’s population increased 29.6%, which is 61,274 people.<\/p>\n More: Port St. Lucie continues to rank nationally for moving activity, growth<\/a><\/p>\n What’s driving Port St. Lucie’s population growth?<\/p>\n Port St. Lucie which accounts for 84% of St. Lucie County’s population increase, according to MIAMI REALTORS\u00ae + RWorld. From July 1, 2024 to July 1, 2025 St. Lucie County’s population increased by 10,857 people.<\/p>\n As of April 2026, the median single-family sales price in Port St. Lucie was $400,000 and $388,057 in St. Lucie County. Palm Beach and Martin counties’ median single-family sales price is $650,000, according to MIAMI REALTORS\u00ae + RWorld.<\/p>\n Top 10 largest U.S. cities with growing populations<\/p>\n This list is as of July 1, 2025.<\/p>\n 1: Port St. Lucie, Florida<\/p>\n 2: Charlotte, North Carolina<\/p>\n 5: Durham, North Carolina<\/p>\n 8: North Las Vegas, Nevada<\/p>\n 10: Raleigh, North Carolina<\/p>\n Olivia Franklin<\/a> is TCPalm’s trending and breaking news reporter. You can contact her at olivia.franklin@tcpalm.com, 317-627-8048 or follow her on X @Livvvvv_5<\/a>.<\/p>\n