Updated Dec. 20, 2025, 8:58 p.m. ET<\/p>\n
The Tampa Bay Buccaneers<\/a> (7-7) and Carolina Panthers<\/a> (7-7) meet Sunday in a Week 16 matchup at Bank of America Field in Charlotte, North Carolina. Kickoff is scheduled for 1 p.m. ET (FOX). Let’s analyze BetMGM Sportsbook’s<\/a> NFL odds around the Buccaneers vs. Panthers odds and make our expert NFL picks and predictions<\/a> for the best bets.<\/p>\n Panthers lead all-time series 25-24, although the Buccaneers swept the season series in 2024. Tampa Bay won 26-23 in overtime last season on Dec. 1, 2024, although Carolina covered as a 6.5-point underdog as the Over (46) cashed. The Bucs have won 5 in a row, and 9 of the past 10 in the series, while going 7-3 against the spread (ATS) in that 10-game span. The Over is 4-1 in the past 5 in the series, too.<\/p>\n Tampa Bay and Carolina are battling for the top spot in the NFC South, and it’s a spot nobody seems to want. The Buccaneers have dropped 5 of the past 6 games, while going 0-6 ATS, including home wins against division rivals the Atlanta Falcons and New Orleans Saints<\/a>. The teams meet again in Week 18<\/p>\n The Bucs lost 29-28 as 6.5-point favorites last week against the Falcons as the Over (43) cashed. Against Atlanta, QB Baker Mayfield threw for 277 yards and 2 TDs, while WR Mike Evans hauled in 6 receptions for 132 yards.<\/p>\n The Panthers inexplicably lost 20-17 in New Orleans last Sunday as a 2.5-point favorite, and they were swept in the 2-game season series by the Saints. QB Bryce Young threw for 163 yards and a TD, while RB Rico Dowdle posted 49 rushing yards and a score. WR Jalen Coker led the way with 60 receiving yards and a TD.<\/p>\n Carolina has dropped 3 of the past 5 games, while going 2-3 ATS in the span. The Under is 4-2 in the past 6 games, too.<\/p>\n Watch the NFL on Fubo!<\/a>Buccaneers at Panthers odds<\/p>\n Provided by BetMGM Sportsbook<\/a>; access USA TODAY Sports Scores and Sports Betting Odds hub<\/a> for a full list. Lines last updated Saturday at 8:49 p.m. ET.<\/p>\n Moneyline (ML): Buccaneers -155 (bet $155 to win $100) | Panthers +130 (bet $100 to win $130)Against the spread: Buccaneers -3 (-105) | Panthers +3 (-115)Over\/Under (O\/U): 45.5 (O: -110 | U: -110)<\/p>\n WIN YOUR FANTASY FOOTBALL LEAGUE! The Huddle<\/a> has been turning players like you into winners for over 25 years. This season, it’s your turn. Custom fantasy football rankings, sleepers and tools are just a click away. Subscribe now<\/a>!<\/p>\n Buccaneers at Panthers key injuries<\/p>\n Buccaneers<\/p>\n Panthers<\/p>\n OT Ikem Ekwonu (knee) questionableDE Tershawn Wharton (hamstring) outWR David Moore (elbow) outLB Trevin Wallace (shoulder) outBuccaneers at Panthers picks and predictionsPrediction<\/p>\n Buccaneers 23, Panthers 19<\/p>\n The BUCCANEERS (-155) aren’t priced out of line if you’re on the conservative side, and you just want to bet a winner straight up without messing around with the points.<\/p>\n Honestly, the way these teams have been playing lately, neither team gives bettors a lot of confidence. But, Mayfield and the Bucs have just a little more experience in these type of games, and they’re a bit deeper on offense.<\/p>\n The lean is to the BUCCANEERS -3 (-105), but don’t get carried away.<\/p>\n Again, Tampa Bay has lost and failed to cover the past 2 games against divisional foes at home as a favorite, so going on the road against the other top team in the division will be no picnic.<\/p>\n However, the Panthers are just too inconsistent to trust. One week they’re topping a top team in the NFC, such as their Week 13 upset of the Los Angeles Rams, and then the next time out, after 2 weeks of preparation following a bye, they’re losing in New Orleans to a team which enters with just 3 wins. Make it make sense.<\/p>\n UNDER 45.5 (-110) might be the best play on the board.<\/p>\n The Under is 4-2 in the past 6 games for the Panthers, and Carolina has mustered 17 or fewer points in 6 of the past 8 outings.<\/p>\n The Buccaneers have cashed the Over in the past 2 games, but on the road, the Under is 3-1 in the past 4 tries. Tampa has managed 17.8 PPG in the past 4 road games.<\/p>\n For more sports betting picks and tips, check out SportsbookWire.com<\/a> and BetFTW<\/a>.<\/p>\n Follow @danieledobish on\u00a0Twitter\/X<\/a>.\u00a0Follow SportsbookWire on Twitter\/X<\/a> and like us on Facebook<\/a>.<\/p>\n Access more NFL coverage:<\/p>\n TheHuddle Fantasy Football<\/a> | BearsWire<\/a> | BengalsWire<\/a> | BillsWire<\/a> | BroncosWire<\/a> | BrownsWire<\/a> | BucsWire<\/a> | CardsWire<\/a> | ChargersWire<\/a> | ChiefsWire<\/a> | ColtsWire<\/a> | CommandersWire<\/a> | CowboysWire<\/a> | DolphinsWire<\/a> | EaglesWire<\/a> | FalconsWire<\/a> | GiantsWire<\/a> | JaguarsWire<\/a> | JetsWire<\/a> | LionsWire<\/a> | NinersWire<\/a> | PackersWire<\/a> | PanthersWire<\/a> | PatriotsWire<\/a> | RaidersWire<\/a> | RamsWire<\/a> | RavensWire<\/a> | SaintsWire<\/a> | SeahawksWire<\/a> | SteelersWire<\/a> | TexansWire<\/a> |\u00a0TitansWire<\/a> | VikingsWire<\/a> | DraftWire<\/a> | TouchdownWire<\/a> | ListWire<\/a><\/p>\n