The No. 2 seed Purdue Boilermakers (27-8) and the No. 15 seed Queens Royals (21-13) will meet on Friday at 7:35 p.m. ET in the opening round of the NCAA Tournament. The matchup airs on truTV.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Purdue vs. Queens Game Info and OddsGame day: Friday, March 20, 2026Game time: 7:35 p.m. ETTV channel: truTVLocation: St. Louis, MissouriArena: Enterprise CenterPurdue vs. Queens Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Purdue win (93.1%)

Before you decide to wager on Purdue-Queens contest (in which Purdue is a 25.5-point favorite and the total has been set at 162.5 points), here are a few betting trends and insights for Friday’s game.

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Purdue vs. Queens: ATS Betting Stats and TrendsPurdue has put together a 15-19-0 record against the spread this season.Queens is 16-16-0 ATS this season.Purdue covers the spread when it is a 25.5-point favorite or more 50% of the time. That’s less often than Queens covers as an underdog of 25.5 or more (100%).The Boilermakers have covered the spread in a lower percentage of their home games than road games. They have covered five times in 17 games at home, and they’ve covered six times in 11 games when playing on the road.The Royals’ winning percentage against the spread at home is .692 (9-4-0). Away, it is .312 (5-11-0).Purdue vs. Queens: Moneyline Betting StatsPurdue has been chosen as the moneyline favorite in 27 games this year and has walked away with the win 20 times (74.1%) in those games.Oddsmakers have given the Boilermakers the best odds of winning they have seen this season with a -20000 moneyline listed for this contest.Queens has put together a 3-9 record in games it was listed as the moneyline underdog (winning 25% of those games).The Royals have never played a game this season with moneyline odds of +3500 or longer.The moneyline set for this matchup implies Purdue has a 99.5% chance of walking away with the win.Purdue vs. Queens Head-to-Head ComparisonPurdue averages 81.7 points per game (54th in college basketball) while allowing 70.1 per outing (70th in college basketball). It has a +403 scoring differential overall and outscores opponents by 11.6 points per game.Purdue’s leading scorer, Braden Smith, ranks 404th in the country scoring 14 points per game.Queens puts up 84.9 points per game (18th in college basketball) while giving up 82.9 per contest (353rd in college basketball). It has a +66 scoring differential and outscores opponents by two points per game.Nasir Mann paces Queens, recording 13.4 points per game (502nd in college basketball).The Boilermakers rank 120th in college basketball at 32.9 rebounds per game. That’s 6.8 more than the 26.1 their opponents average.Trey Kaufman-Renn averages 8.5 rebounds per game (ranking 51st in college basketball) to lead the Boilermakers.The Royals are 239th in the nation at 31 rebounds per game. That’s similar to the 31.4 their opponents average.Mann leads the team with 5.8 rebounds per game (327th in college basketball).Purdue scores 110.4 points per 100 possessions (third in college basketball), while giving up 94.8 points per 100 possessions (167th in college basketball).The Royals rank 30th in college basketball averaging 105.6 points per 100 possessions on offense, and defensively are 345th, allowing 103.2 points per 100 possessions.

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