A plane carrying six people has disappeared off the coast of Nantucket, leading the Coast Guard to launch a desperate air and surface search.

The Gulfstream G100, a medical transfer aircraft, was flying from Bermuda to Boston at 12:41 a.m. Saturday and lost contact with the Federal Aviation Administration before it was scheduled to land at 1:25 a.m., according to the USCG and FlightAware.

The FAA confirmed that six people were on the flight, which departed from L.F. Wade International Airport in Bermuda and was headed to Boston Logan International Airport.

A white and black medevac airplane with landing gear deployed, in flight against a clear sky.The medical transfer aircraft lost contact with the Federal Aviation Administration after it plummeted from 23,500 feet to 11,000 feet in just three minutes.

There were four crew members and two passengers on board, a spokesperson for L.F. Wade International Airport said in a statement.

Four of the passengers are Canadian nationals and two are Bermudian natives, according to Toronto’s City News.

The flight plummeted from 23,500 feet to 11,000 feet in just three minutes starting at 1:04 a.m., according to FlightAware data.

“We are praying for a safe outcome,” a spokesperson for Latitude Air Ambulance, which owns the missing plane, told City News.

Federal authorities are currently scouring the seas for the plane or wreckage.

“The FAA issued a Search and Rescue Alert Notice for Gulfstream G-100 around 1:20 a.m. local time on Saturday, Oct. 3,” an FAA spokesperson told The Post.

“The FAA is coordinating with the Rescue Coordination Center and the U.S. Coast Guard to locate the aircraft,” the statement concluded.

A map of the Atlantic Ocean and eastern North America showing a flight path from Massachusetts to Bermuda, with a plane currently in mid-flight over the ocean.The flight disappeared off the coast of Nantucket after departing from L.F. Wade International Airport in Bermuda.

The Coast Guard was alerted by the FAA at approximately 2 a.m., the military branch told The Post.

“The current search area is offshore of Nantucket. Coast Guard, air and surface crews are actively responding, including: planes HC-144 and MH-60 Jayhawk helicopter from Air Station Cape Cod; a 47-foot Motor Lifeboat from Station Brant Point; and a Fast Response cutter from ship USCGC William Sparling,” the agency said.

Additionally, HC-130 Hercules from Air Station Elizabeth City has been deployed, according to the USCG.

“The Coast Guard will continue searching and provide additional information as it becomes available,” the group said.

A Logan Airport official confirmed the flight didn’t arrive as scheduled and offered condolences to the passengers and their families.

“Our thoughts are with those on board and their loved ones as the search continues,” a Massport spokesperson said in a statement.