A five-alarm fire tore through a three-story building in Queens early Tuesday, injuring six people, including five firefighters, officials said.

The FDNY received a call about the fire on Madison Street, near Seneca and Onderdonk avenues in Ridgewood, around 3:30 a.m. Fire officials reported that the blaze began on the first floor and quickly increased to five alarms an hour later.

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A five-alarm fire broke out on Madison Street in Ridgewood, Queens, early Tuesday

Six people were injured, including five firefighters and one civilian; all were transported to local hospitals

More than 270 firefighters and emergency personnel responded, and operations remained ongoing as of 8:45 a.m.

At a morning press briefing, FDNY Chief John Esposito said the fire soon spread to all floors, and adjacent buildings.

“The roof has collapsed into the top floor,” he said. “We vacated four of the buildings behind us.”

Esposito said six people suffered minor injuries, including one firefighter who was struck in the head by an air conditioning unit that fell out of a window. All were transported to area hospitals without incident, he said.

Mayor Zohran Mamdani said the city responded with a “whole-of-government approach” involving FDNY, EMS, the Department of Buildings and the MTA.

“More than 271 responders came to the scene. We are so thankful for their work in ensuring that even at a fire of this scale, there was no loss of life. Six New Yorkers have been injured — five firefighters and one civilian. We are continuing to keep them in our prayers,” he said. “While there wasn’t a loss of life, for the many New Yorkers affected by this fire, this will irrevocably change their lives.”

“This is the second five-alarm fire this year, and we know that it is thanks to those who run towards the fire that so many New Yorkers were able to run towards safety,” Mamdani added.

A reception center for affected families has opened at P.S. 239, located at 1715 Weirfield St. The American Red Cross is also registering residents for assistance.

As of 8:45 a.m., the fire had not yet been fully extinguished, and operations remained ongoing, the FDNY said.