UPDATE #2: A total of 37 vehicles were involved in the crash. Interstate 81 has reopened in both northbound and southbound directions.
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UPDATE #1: On Thursday, January 15, 2026, at about 2:20 p.m., State Police responded to a report of a multi-vehicle crash on I-81 southbound, south of Exit 73 in the town of LaFayette.
The preliminary investigation has determined that the primary crash involved approximately 18 vehicles, including three tractor-trailers. There were also a number of smaller crashes. It is estimated that a total of approximately 30 vehicles were involved in the crash, which is believed to be weather-related.
Four patients have been transported to Upstate Medical Hospital, three to Crouse Hospital, and one to Upstate Community Hospital. Two patients have serious, but not life-threatening injuries.
Those individuals who were not injured in the crash were transported from the scene to the LaFayette Fire Department by a CENTRO bus.
I-81 southbound at Exit 73 will remain closed while the crash is cleared, which is expected to take about two hours. One northbound lane at Exit 67 in Tully is now open.
The NYSP Unmanned Aerial Systems Unit, Bureau of Criminal Investigation and Commercial Vehicle Enforcement Unit are on scene assisting with the investigation.
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Original Release:
New York State Police are currently on scene of a multiple vehicle collision on Interstate 81 southbound in the town of LaFayette.
At this time, traffic is significantly impacted in the area as emergency crews work to clear the scene and assist those involved. Motorists should expect delays and are encouraged to seek alternate routes if possible. Traffic is being detoured off at Exit 73, with motorists directed to take State Route 20 onto US-11.
Interstate 81 northbound at the Tully exit is currently closed so emergency vehicles can respond to the scene.
This is an active investigation, and additional information will be released as soon as it becomes available.