A hit-and-run driver fatally struck a 44-year-old man in an Upper East Side crash early Friday, officials said.
The deadly impact happened about nine hours after another driver killed an e-bike rider and wounded four others in a wild high-speed crash in Harlem.
The victim was on E. 61st St. and Lexington Ave. around 4:50 a.m. when a car heading south on Lexington Ave. plowed into him, horrified witnesses told police.
The driver never stopped.
First responders found the victim crumpled in the roadway suffering from massive injuries across his body.

Theodore Parisienne / New York Daily News
Police investigate after a hit-and-run driver fatally struck a 44-year-old man on E. 61st St. and Lexington Ave. Friday morning. (Theodore Parisienne / New York Daily News)
EMS rushed him to New York Presbyterian/Weill Cornell Medical Center, where he died of his injuries. The victim’s name was not immediately released as cops tried to locate his family.
Police did not immediately provide a description of the car.
Vincent Spano, a 33-year-old resident of Palm Harbor, Fla., was arrested around 7 a.m. Friday after he showed up at the NYPD’s 76th Precinct stationhouse in Brooklyn and told police that he was responsible for the crash, cops said. He was charged with leaving the scene of a fatal crash and failure to exercise due care.
Before Spano turned himself in, NYPD detectives were scouring the area for surveillance video in the hopes of tracking the driver down.
At about 8 p.m. Thursday, a 49-year-old man speeding through Harlem in a Hyundai Tucson lost control and struck two e-bike riders and four vehicles, including an unoccupied NYPD vehicle, cops said.
The crash took place near W. 125th St. and Frederick Douglass Blvd., less than a block away from the famed Apollo Theater, cops said.
The vehicle went on to strike a Toyota RAV4 and a Lexus, before careening off an unoccupied NYPD patrol car and becoming wedged beneath an 18-wheeler truck, police said.
One of the injured cyclists was taken to Mt Sinai, where he died, cops said. The other cyclist was taken to Harlem Hospital in critical condition.
The Toyota driver, a 40-year-old man, and two occupants of the Lexus, both men aged 28 and 23, were all taken to Harlem Hospital in stable condition.
The Hyundai driver, Kevin Crosby, 49, of the Bronx, was taken into custody following the crash and charged with manslaughter and driving while impaired.