A large winter storm that could bring some of the biggest snow of the season to the Central U.S. and Rockies is expected to significantly impact travel plans for millions of people across 40 states returning home from their Thanksgiving holiday starting on Black Friday.

The FOX Forecast Center said a dip in the jet stream combined with arctic air in the northern tier of the U.S. will help spawn an area of low pressure across the central Rockies and Plains by the weekend, bringing snow Friday into early Saturday. 

Several inches of snow are expected in higher elevations of the Rocky Mountains, and Denver is expecting 1–3 inches of snow by Monday, breaking a 220+ day streak with no snowfall. 

By Saturday, the storm is expected to intensify as it moves into the Plains. 

In the Midwest, 5–8 inches of snow will fall across parts of Iowa, southern Wisconsin and Illinois. 

Cities like Des Moines, Milwaukee, Chicago and Madison, Wisconsin, are likely to see significant snowfall. 

Weekend storm to wreak havoc on post-Thanksgiving travel plans this weekend. ZUMAPRESS.com

Snow could lead to travel issues at major airports like Chicago O’Hare and Midway, Milwaukee Mitchell International. REUTERS

Several inches of snow are expected in higher elevations. Getty Images

In Chicago, 8-12 inches of snow is forecast by the weekend’s end. 

The closer to the Great Lakes, the more likely it is to see much higher snow totals, according to the FOX Forecast Center. 

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If the forecast verifies for Chicago, it could be one of the snowiest two-day November snow events in the city’s history, according to the FOX Forecast Center. 

As people begin returning home from their holiday plans starting Friday, snow could lead to travel issues at major airports like Chicago O’Hare and Midway, Milwaukee Mitchell International and Detroit Metropolitan. 

By Saturday, the storm is expected to intensify as it moves into the Plains.

Travel impacts could last through Monday.  Getty Images

Snow will push into the Northeast and New England Saturday and last through Monday. 

Travel impacts could last through Monday. 

To the south, gusty winds, heavy rain and thunderstorms are also possible on the warmer side of this system. 

Heavy rain could move through already-drenched areas of the South, in cities like Dallas, Nashville and Little Rock, Arkansas. 

A level 1 out of 4 flash flood risk has already been issued across eastern Texas, Arkansas and Louisiana into Saturday as this sprawling storm pushes east. A widespread 1-2″ of rain is possible through Sunday. 

Snow will push into the Northeast and New England Saturday and last through Monday. 

Thanksgiving storm leads to treacherous travel conditions across Great Lakes 

The biggest lake-effect snow event of the season thus far is pummeling the Great Lakes Snowbelt, and is expected to deliver feet of snow through Black Friday, creating long periods of life-threatening travel conditions across major Interstate highways this Thanksgiving holiday.

Blizzard Warnings in the Upper Peninsula of Michigan persist through Friday. 

When it comes to the post-Thanksgiving storm, forecast models remain uncertain about which areas are likely to see the most amount of snow for now, but as Thanksgiving nears, things will become clear.