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\t\t\t\t\t\t\t\t\t\t\t\tby Keka Ara\u00fajo <\/a><\/p>\n November 27, 2025<\/p>\n The “Genesis Mission” Executive Order draws a direct analogy to the Manhattan Project to convey the urgency, national scope, and ambition of the new AI initiative.<\/p>\n President Donald J. Trump signed a sweeping Executive Order on Nov. 24, officially launching <\/a>the \u201cGenesis Mission,\u201d a dedicated, coordinated national initiative to secure global technological supremacy by accelerating the application of artificial intelligence to scientific discovery.<\/p>\n The order frames the effort as a \u201chistoric national effort, comparable in urgency and ambition to the Manhattan Project\u201d that will leverage decades of federal scientific investment to solve \u201cthe most challenging problems of this century.\u201d<\/p>\n The mandate designates the Department of Energy (DOE) as the lead agency, tasking the Secretary of Energy with establishing and operating the American Science and Security Platform (Platform)\u2014a secure, integrated AI infrastructure designed to harness the world\u2019s most extensive collection of federal scientific datasets.<\/p>\n AI Acceleration as a National Security Imperative<\/p>\n The Genesis Mission seeks to create scientific foundation models and AI agents capable of testing new hypotheses, automating research workflows, and dramatically accelerating breakthroughs across critical national domains.\u00a0<\/p>\n The President asserts the mission will \u201cstrengthen national security, secure energy dominance, enhance workforce productivity, and multiply the return on taxpayer investment into research and development.\u201d<\/p>\n Priority areas identified for the mission include advanced manufacturing, biotechnology, critical materials, nuclear fission and fusion energy, quantum information science, and semiconductors and microelectronics.<\/p>\n The DOE Secretary is mandated to integrate federal resources, including DOE national laboratory supercomputers and secure cloud-based computing environments, into the unified Platform. This infrastructure is intended to serve as the core resource for model training, simulation, and inference across the interagency effort.<\/p>\n The Secretary is also directed to establish formal mechanisms for collaboration with external entities possessing advanced AI capabilities, including through standardized partnership frameworks, user facility partnerships, and clear policies for the commercialization of intellectual property developed under the mission.<\/p>\n A crucial and challenging component of the mission is data integration. Within 120 days of the order\u2019s issuance, the Secretary must identify initial data assets and develop a plan for securely incorporating datasets from federally funded research, academia, and approved private-sector partners. Given the national security implications, the Platform must adhere to strict security requirements, including classification and supply chain security standards.<\/p>\n The order tasks the Assistant to the President for Science and Technology (APST) with providing general leadership and coordination through the National Science and Technology Council (NSTC). To maximize national engagement, the Executive Order emphasizes the need for broad collaboration. The APST and the Secretary are mandated to establish competitive programs for research fellowships, internships, and apprenticeships focused on AI-enabled science, with placements at DOE national laboratories to provide hands-on training and access to the Platform.<\/p>\n The \u201cGenesis Mission\u201d Executive Order draws a direct analogy to the Manhattan Project to convey the urgency, national scope, and ambition of the new AI initiative.<\/p>\n What Was The Manhattan Project?<\/p>\n