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Blood banks around the country were already trying to recover from a severe winter shortage when this week’s snowstorm caused a setback in those efforts with additional cancelled donor drives and appointments.

Meanwhile, demand for blood at hospitals and health centers continues to outpace supply locally and nationally at a concerning rate, said leaders at the American Red Cross. They are urging people to donate as soon as possible.

“Because of all the weather and colds and flu, and it was the holiday season, the supply has just not rebounded the way that we have seen happen in the past,” said Jennifer Graham, CEO of the Red Cross’ Southeastern Pennsylvania Region. “The need for blood doesn’t take a holiday, it doesn’t take a vacation, it doesn’t take a sick day. It takes everybody giving, every single day.”

The latest calls to action follow the American Red Cross’ declaration of a severe national blood shortage in January. The national blood supply fell by about 35% in just a month’s time as donations slowed.

“That’s a big number,” Graham said. “I’ve been at the Red Cross for over 26 years, and to see that kind of number gives me pause.”

All nine American Red Cross donation centers in the Southeastern Pennsylvania Region were forced to close Monday and Tuesday following this week’s storm, leading to a loss of about 1,000 blood and platelets donations, Graham said.

Keeping regional blood banks stocked and able to support local hospitals and health systems is a constant effort, she said. As there is no alternative to human blood for most medical uses, this effort relies heavily on volunteer donors.

An estimated 62% of people in the United States are eligible to donate blood because they’re old enough, in good health and have no or few medical complications, but only about 3% ultimately do each year, according to America’s Blood Centers.

That means blood banks like the ones in Philadelphia, its suburbs, Delaware and New Jersey have less at the ready to respond to a major disaster or event.

Blood banks may also have to triage daily supply and distributions to local health centers, Graham said, which often need donated plasma, platelets and whole blood for all kinds of patients and conditions.

“It’s also programs to support cancer patients, our sickle cell patients, some of our more rare blood donor types,” she said, “making sure that we have that universal donor of O-negative ready and available on those shelves for the emergencies and traumas that come in.”