{"id":213629,"date":"2026-06-08T12:52:12","date_gmt":"2026-06-08T12:52:12","guid":{"rendered":"https:\/\/www.newsbeep.com\/us-pa\/213629\/"},"modified":"2026-06-08T12:52:12","modified_gmt":"2026-06-08T12:52:12","slug":"lukas-bethlehem-defined-mtc01-vs-fmt-for-recurrent-c-difficile-infection","status":"publish","type":"post","link":"https:\/\/www.newsbeep.com\/us-pa\/213629\/","title":{"rendered":"Lukas Bethlehem: Defined MTC01 vs FMT for Recurrent C. difficile Infection"},"content":{"rendered":"

Lukas Bethlehem, Former Scientist PharmaBiome AG, shared a post on\u00a0LinkedIn<\/a>:<\/p>\n

\u201cDeeply honored to share that our work has been published in Nature Medicine (Nature Portfolio):<\/p>\n

\u201915-strain live biotherapeutic product or same-donor fecal microbiota transplant for recurrent Clostridioides difficile infection: a randomized phase 1b trial\u2019.<\/p>\n

We present a new platform for manufacturing defined microbial consortia that is affordable, and safe for use in human microbiome clinical trials. To accelerate the field, we are openly sharing the full regulatory (IND) and manufacturing (MBR) documentation alongside the publication \u2014 because we believe a broad clinical foundation will bolster trust, investment and regulatory clarity for the field.<\/p>\n

In a first-of-its-kind randomized clinical trial, we directly compared an in vitro-manufactured defined microbial consortium (MTC01) to its matched donor fecal microbiota transplant (FMT) from the same donor.<\/p>\n

The result: bacterial strains manufactured with our platform retain their efficacy in treating recurrent C. difficile infection (rCDI). Defined products like MTC01 offer clear advantages over undefined FMT \u2014 including a defined safety profile and consistent, reproducible efficacy.<\/p>\n

Trial outcomes at a glance:<\/p>\n

Safety: No treatment-related adverse events among 18 patients
\nEfficacy: rCDI prevention in 7\/9 MTC01 and 8\/9 FMT patients
\nEngraftment: High and durable for both treatments; most reliable for MTC01 at high dose<\/p>\n

Are you interested in safely and affordably translating a microbiota therapeutic to the clinic? Fill in the form in the comments or reach out to me directly.
I am actively scouting for institutions in Europe to establish a translational center with our platform.<\/p>\n

A heartfelt thank you to the entire team at the Icahn School of Medicine at Mount Sinai and our partners at Massachusetts General Hospital and Duke University Health System for making this vision a reality. And a special acknowledgment to Jeremiah Faith \u2014 an exceptional leader and mentor.\u201d<\/p>\n

Related content<\/a><\/p>\n

Exciting News for Translating the Microbiome Into Human Health<\/a><\/p>\n

Title: 15-strain live biotherapeutic product or same donor fecal microbiota transplant for recurrent Clostridioides difficile infection: a randomized phase 1b trial<\/p>\n

Read the article<\/a><\/p>\n

\"Lukas<\/p>\n

Other articles featuring Lukas Bethlehem<\/a> on OncoDaily.<\/p>\n","protected":false},"excerpt":{"rendered":"Lukas Bethlehem, Former Scientist PharmaBiome AG, shared a post on\u00a0LinkedIn: \u201cDeeply honored to share that our work has…\n","protected":false},"author":2,"featured_media":210920,"comment_status":"","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[153,155,154],"class_list":["post-213629","post","type-post","status-publish","format-standard","has-post-thumbnail","category-bethlehem","tag-bethlehem","tag-bethlehem-headlines","tag-bethlehem-news"],"_links":{"self":[{"href":"https:\/\/www.newsbeep.com\/us-pa\/wp-json\/wp\/v2\/posts\/213629","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.newsbeep.com\/us-pa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.newsbeep.com\/us-pa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-pa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-pa\/wp-json\/wp\/v2\/comments?post=213629"}],"version-history":[{"count":0,"href":"https:\/\/www.newsbeep.com\/us-pa\/wp-json\/wp\/v2\/posts\/213629\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-pa\/wp-json\/wp\/v2\/media\/210920"}],"wp:attachment":[{"href":"https:\/\/www.newsbeep.com\/us-pa\/wp-json\/wp\/v2\/media?parent=213629"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-pa\/wp-json\/wp\/v2\/categories?post=213629"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.newsbeep.com\/us-pa\/wp-json\/wp\/v2\/tags?post=213629"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}