Dec. 31, 2025, 11:45 a.m. ET

The New York Knicks (23-9) face the San Antonio Spurs (23-9) Wednesday at Frost Bank Center in San Antonio, Texas. Tip-off set for 7 p.m. ET (NBA TV). Let’s analyze BetMGM Sportsbook’s NBA odds around the Knicks vs. Spurs odds and make our expert NBA picks and predictions for the best bets.

Season series: First regular-season meeting; Knicks won 124-113 in NBA Cup final

The Knicks won their third straight game Monday, edging the New Orleans Pelicans 130-125. New York failed to cover as a 9.5-point road favorite and the Over (253) cashed. G Jalen Brunson finished with 28 points and 10 assists, scoring twice in the final 1:06. F OG Anunoby added 23 points and 11 rebounds, while F Mohamed Diawara posted a career-high 18 points.

San Antonio dropped its second straight Monday night, falling 113-101 to the Cleveland Cavaliers. The Spurs failed to cover as 1.5-point home underdogs and the Under (239.5) cashed. C Victor Wembanyama finished with 26 points and 14 rebounds for his 10th double-double. G Stephon Castle added 15 points, while G De’Aaron Fox scored 14 in his return after missing 1 game with adductor tightness.

In their last meeting (Dec. 16), the Knicks beat the Spurs 124-113 in the NBA Cup final in Las Vegas. New York covered as a 2.5-point favorite and the Under (233) cashed.

Watch the NBA on Fubo!Knicks at Spurs odds

Provided by BetMGM Sportsbook access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:45 a.m. ET.

Moneyline (ML): Knicks +110 (bet $100 to win $110) | Spurs -135 (bet $135 to win $100)Against the spread (ATS): Knicks +2.5 (-110) | Spurs -2.5 (-110)Over/Under (O/U): 235.5 (O: -115 | U: -105)Knicks at Spurs key injuries

Knicks

G Josh Hart (ankle) outG Tyler Kolek (ankle) probableC Mitchell Robinson (ankle) outC Landry Shamet (shoulder) out

Spurs

G Stephon Castle (thumb) questionableG Devin Vassell (adductor) out

For most recent updates: Official NBA injury report.

Knicks at Spurs picks and predictionsPrediction

Spurs 121, Knicks 118

BET SPURS (-135).

I’m backing San Antonio to bounce back here. The Spurs hit a small skid after that post–NBA Cup surge, but this team hasn’t lost 3 straight all season, and that matters. They’ve shown an ability to respond, especially at home, where their energy and pace tend to look different.

Wembanyama is still on a minutes cap, but even in shorter bursts he warps the game. The Spurs don’t rely solely on him, either. Their guard rotation pushes tempo, forces mismatches and creates transition chances — a problem for a Knicks team that prefers to play slower and operate in the half court through Brunson.

New York has been good offensively, but this is a tough spot on the road against a team that can attack from multiple angles. San Antonio’s size on the perimeter can bother Brunson, and if the Spurs can speed this game up even slightly, it tilts in their favor. The Knicks defend well, but they aren’t dominant enough to shut down all of San Antonio’s options.

I also like the situational angle. The Spurs are back home, motivated and historically respond well after consecutive losses. New York is solid, but this feels like a game where San Antonio’s balance and athleticism show up late.

In what I expect to be a tight, competitive matchup, I’m taking the Spurs to win outright on their home floor.

PASS.

If you want the slightly better odds with this small spread, go for it. I’ll keep my bet to the moneyline.

BET OVER 235.5 (-115).

These teams have cleared the number in 7 of the last 10 meetings, and the Knicks have leaned Over in 7 of their last 10 overall. New York plays fast and ranks near the top of the league offensively, and with Wembanyama back, San Antonio’s scoring ceiling jumps. I’m expecting pace, points and a total that gets pushed past the number.

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