March 21, 2026, 3:33 a.m. ET

The Texas A&M Aggies (22-11) and No. 5 Houston Cougars (29-6) clash in the second round of the NCAA Tournament Saturday. Tip from Paycom Center in Oklahoma City, Oklahoma, is scheduled for 6:10 p.m. ET (TNT). Let’s analyze NCAA basketball odds around the Texas A&M vs. Houston and make our expert college basketball picks and predictions for the best bets.

Texas A&M, which entered as the No. 10 seed in the South Region after losing to Oklahoma in the SEC Tournament, eased past the 7-seeded Saint Mary’s Gaels 63-50 on Thursday. The Aggies covered as a 2.5-point underdog with the Under (148.5) hitting with ease. F Rashaun Agee led all scorers with 22 points and added 9 rebounds in the victory.

Houston, seeded No. 2 after falling to Arizona in the Big 12 tournament championship game, dominated 15 seed Idaho 78-47 Thursday, covering as a 23.5-point favorite with the Under (137.5) hitting. G Kingston Flemings scored a game-high 18 points while F Chris Cenac Jr. dominated the glass with 18 rebounds.

– Rankings: USA TODAY Sports Coaches Poll

Watch NCAA basketball on Fubo!Texas A&M vs. Houston odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 3:25 a.m. ET.

Moneyline (ML): Texas A&M +400 (bet $100 to win $400) | Houston -550 (bet $550 to win $100)Against the spread (ATS): Texas A&M +10.5 (-105) | Houston -10.5 (-115)Over/Under (O/U): 142.5 (O: -105 | U: -115)Texas A&M vs. Houston picks and predictionsPrediction

Houston 73, Texas A&M 61

PASS.

There is minimal value on the Cougars (-550), who looked outstanding in the opening round and have won 6 of their last 7 overall.

BET HOUSTON -10.5 (-115).

The Cougars have been great on defense recently, holding opponents to 47 points in 2 of their last 3 games, while the Aggies have scored just 63 points in back-to-back games. The Cougars are in familiar territory in the tournament, giving them a major advantage. The Aggies are just 1-3 over their last 4 games as underdogs, while the Cougars have covered in back-to-back games as favorites.

LEAN UNDER 142.5 (-115).

The Cougars’ defense will be the primary reason for the Under hitting. They have hit the Under in 3 of their last 4 games and do a phenomenal job of controlling the pace and confusing opposing offenses. They have allowed 66 or fewer points in 5 of their last 7.

The Aggies have hit the Under in back-to-back games and 3 of their last 5. They have shown major inconsistencies recently and should be expected to have a difficult time against a tough Cougars team.

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