Officers responded around 9:30 p.m. to the intersection of Airport Boulevard and Oak Springs Drive, where the scooter rider and a vehicle collided, police said.
The scooter rider died at the scene. Police said both people involved in the crash were adults but did not identify the person who was killed.
The driver remained at the scene, and no arrest had been made as of Wednesday morning.
The intersection was closed while investigators processed the scene but reopened by about 1:15 a.m. Wednesday.
The American-Statesman requested additional information from APD but did not receive a response before publication.