Walker was removed from the game due to “right hip tightness,” the Astros said, while Peña exited due to a right hamstring cramp.
Manager Joe Espada did not have a further update on either player postgame but said both were going for tests. Neither Peña nor Walker were available for comment after the game.
Peña, batting in the bottom of the third, fouled off a pitch and was visited by Espada and a team trainer. Peña shook out his right leg during the discussion. He finished the at-bat, striking out swinging, and was replaced on defense by Nick Allen in the fourth.
Espada said the issue Saturday was “kind of similar. It looked like a cramp (on) the pitch when I went out there. And then once he took the last swing, it cramped up again, so we just took him out to make sure that we take care of it.”
In the bottom of the fourth, Walker took a check swing and promptly reached for and stretched out his right side. Espada and a trainer emerged again from the dugout. Walker was removed mid-at-bat, with LaMonte Wade Jr. finishing the at-bat and staying in the game at first base.
With the Astros six games under .500 after their loss Saturday, any absence for Peña or Walker, two of their everyday players, would be ill-timed. Walker has played in all but two of 100 games for Houston this season, while Peña has played in 53 games due to various injuries.