March 21, 2026, 11:49 a.m. ET<\/p>\n
The Indiana Pacers<\/a> (15-55) pay a visit to the San Antonio Spurs<\/a> (52-19) Saturday. Tip-off from Frost Bank Center in San Antonio, Texas, is set for 8 p.m. ET. Let’s analyze NBA odds around the Pacers vs. Spurs odds and make our expert NBA picks and predictions<\/a> for the best bets.<\/p>\n Season series: Spurs lead 1-0<\/p>\n Indiana was handed a 127-119 loss by the Portland Trail Blazers Wednesday, covering as a 12.5-point home underdog while the Over (232.5) hit. C Ivica Zubac had 18 points and 8 boards, but he suffered a broken rib, which could cost him the rest of the season. The Pacers have lost 15 straight, giving up at least 120 points in 12 of those losses.<\/p>\n San Antonio escaped with a 101-100 win over the Phoenix Suns Thursday while failing to cover as a 9.5-point home favorite as the Under (227.5) hit. C Victor Wembanyama put up 34 points and 12 rebounds in the win, including the game-winning jumper. The Spurs have won 4 straight and have held opponents under 105 points in 3 of those wins. They’re 9-1 in the last 10.<\/p>\n The Spurs picked up a 123-113 win over the Pacers Jan. 2 while covering as 5.5-point road favorites, as the Under (238.5) cashed. G De’Aaron Fox scored 24 points to lead the Spurs, and G Dylan Harper shone with 22 points off the bench in the win. The Spurs led by 10 in both the rebounding battle and points in the paint.<\/p>\n Watch the NBA on Fubo!<\/a>Pacers at Spurs odds<\/p>\n Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub<\/a> for a full list. Lines last updated at 11:35 a.m. ET.<\/p>\n Moneyline (ML): Pacers +1150 (bet $100 to win $1,150) | Spurs -2500 (bet $2,500 to win $100)Against the spread (ATS): Pacers +18.5 (-105) | Spurs -18.5 (-115)Over\/Under (O\/U): 233.5 (O: -115 | U: -105)Pacers at Spurs key injuries<\/p>\n Pacers<\/p>\n G Johnny Furphy (knee) outG Tyrese Haliburton (Achilles) outG Quenton Jackson (calf) questionableG T.J. McConnell (hamstring) questionableG Andrew Nembhard (calf) questionableF Aaron Nesmith (ankle) questionableC Micah Potter (triceps) questionableG Ben Sheppard (ankle) questionableF Pascal Siakam (knee) questionableF Obi Toppin (foot) questionableC Ivica Zubac (rib) out<\/p>\n Spurs<\/p>\n G Stephon Castle (hip) questionable<\/p>\n For most recent updates: Official NBA injury report<\/a>.<\/p>\n Pacers at Spurs picks and predictionsPrediction<\/p>\n Spurs 120, Pacers 98<\/p>\n PASS.<\/p>\n The Spurs are the far better team, so covering as -2500 favorites won’t be a problem here. However, they are not worth the risk of backing on the ML as such heavy favorites, so pass and bet on the spread and\/or total instead.<\/p>\n BET SPURS -18.5 (-115).<\/p>\n San Antonio has covered the spread in 6 of its last 10 games, while the Pacers are just 2-8 ATS in their last 10 games. The Spurs are also 38-31-2 against the spread this season, much better than Indiana’s 30-40 ATS record. In the last 7 matchups between these squads, the Spurs have covered ATS 5 times, including in 2 of the last 3 meetings in San Antonio.<\/p>\n LEAN UNDER 233.5 (-105).<\/p>\n The Under has hit in 3 of San Antonio’s last 4 games and is 41-30 for the Spurs this season. For Indiana, the Under is 36-34 on the season. The Under has also hit in 3 of the last 4 matchups between these squads that took place in San Antonio.<\/p>\n This is a LEAN because Indiana’s defense is terrible, but the Under is still safer here given San Antonio’s elite defense.<\/p>\n For more sports betting picks and tips, check out SportsbookWire.com<\/a> and BetFTW<\/a>.<\/p>\n Follow SportsbookWire on Twitter\/X<\/a> and like us on Facebook<\/a>.<\/p>\n Access more NBA coverage:<\/p>\n HoopsHype<\/a> | Celtics Wire<\/a> | Nets Wire<\/a>\u00a0|\u00a0Rockets Wire<\/a>\u00a0|\u00a0Sixers Wire<\/a>\u00a0|\u00a0Thunder Wire<\/a>\u00a0|\u00a0Warriors Wire<\/a>\u00a0| LeBron Wire<\/a> |\u00a0Rookie Wire<\/a>\u00a0|\u00a0List Wire<\/a><\/p>\n Our team of savvy editors independently handpicks all recommendations. If you purchase through our links, the USA TODAY Network may earn a commission. Prices were accurate at the time of publication but may change.<\/p>\n Gambling involves risk. 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