Updated Dec. 10, 2025, 5:14 p.m. ET<\/p>\n
The San Antonio Spurs<\/a> (16-7) and Los Angeles Lakers<\/a> (17-6) meet at 10 p.m. ET Wednesday in an NBA Cup quarterfinal from Crypto.com Arena in Los Angeles, California. Let’s analyze BetMGM Sportsbook’s<\/a> NBA odds around the Spurs vs. Lakers odds and make our expert NBA picks and predictions<\/a> for the best bets.<\/p>\n Season series: Lakers lead 1-0 with 118-116 home win Nov. 5<\/p>\n The Spurs beat the New Orleans Pelicans 135-132 Monday, but failed to cover as an 8-point road favorite as the Over (238.5) cashed with ease. Seven Spurs scored in double figures, led by F Harrison Barnes’ 24 points. San Antonio has won 3 of its last 4 games, going 2-2 against the spread (ATS). It is 12-10-1 ATS on the season.<\/p>\n The Lakers finished up a 3-game road trip with a 112-108 win over the Philadelphia 76ers Sunday, covering as a 2.5-point favorite as the Under (234) hit. G Luka Doncic (31) and F LeBron James (29) combined for 60 points on 21-for-41 shooting. Los Angeles won its last 7 games in November and has gone 2-2 in December. In that 11-game stretch, it has gone 7-4 ATS. The Lakers are 15-8 ATS on the season.<\/p>\n Watch the NBA on Fubo!<\/a>Spurs at Lakers odds<\/p>\n Provided by BetMGM Sportsbook<\/a>; access USA TODAY Sports Scores and Sports Betting Odds hub<\/a> for a full list. Lines last updated at 6:22 a.m. ET.<\/p>\n Moneyline (ML): Spurs +185 (bet $100 to win $185) | Lakers -225 (bet $225 to win $100)Against the spread (ATS): Spurs +5.5 (-102) | Lakers -5.5 (-118)Over\/Under (O\/U): 238.5 (O: -110 | U: -110)Spurs at Lakers key injuries<\/p>\n Spurs<\/p>\n C Victory Wembanyama (calf) out<\/p>\n Lakers<\/p>\n F Maxi Kleber (lumbar strain) questionable<\/p>\n For most recent updates: Official NBA injury report<\/a>.<\/p>\n Spurs at Lakers picks and predictionsPrediction<\/p>\n Lakers 124, Spurs 117<\/p>\n PASS.<\/p>\n The Lakers (-225) are the healthier side, and the home crowd should be fired up for the NBA Cup battle. Expect L.A. to come out on top, but avoid an expensive moneyline wager.<\/p>\n BET LAKERS -5.5 (-115).<\/p>\n The Lakers have gone 5-2 ATS across their last 7 home games. Their offense has been on a torrid pace, scoring at least 123 points in 4 of their last 7 games. Los Angeles is 5-3 ATS in its last 8 games as a favorite as well.<\/p>\n The Spurs had an unimpressive win over the Pelicans and have gone just 1-2 ATS in their last 3 games as an underdog. Without Wembanyama they have struggled immensely on the defensive end, which should be picked apart by Los Angeles. San Antonio has allowed at least 119 points in 5 of its last 6 games.<\/p>\n Back LAKERS -5.5 (-115).<\/p>\n BET OVER 238.5 (-110).<\/p>\n Neither side has been known for its defense this season. Los Angeles has allowed at least 118 points in 6 of its last 7 games and in 4 straight at home. It is 6-1 O\/U in those contests.<\/p>\n The Spurs have gone Over in 5 of their last 6 games. In their last 5 games (all without Wembanyama), they rank eighth in the NBA in pace. They will push the tempo Wednesday night, which should lead to numerous scoring chances.<\/p>\n Take OVER 238.5 (-110).<\/p>\n For more sports betting picks and tips, check out SportsbookWire.com<\/a> and BetFTW<\/a>.<\/p>\n Follow SportsbookWire on Twitter\/X<\/a> and like us on Facebook<\/a>.<\/p>\n Access more NBA coverage:<\/p>\n HoopsHype<\/a> | Celtics Wire<\/a> | Nets Wire<\/a>\u00a0|\u00a0Rockets Wire<\/a>\u00a0|\u00a0Sixers Wire<\/a>\u00a0|\u00a0Thunder Wire<\/a>\u00a0|\u00a0Warriors Wire<\/a>\u00a0| LeBron Wire<\/a> |\u00a0Rookie Wire<\/a>\u00a0|\u00a0List Wire<\/a><\/p>\n Our team of savvy editors independently handpicks all recommendations. If you purchase through our links, the USA Today Network may earn a commission. Prices were accurate at the time of publication but may change.<\/p>\n Gambling involves risk. 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