Who is the favorite to win?

Brendan O’Sullivan lists the odds for the 2025 Cook Out Southern 500 on DraftKings Sportsbook.

The NASCAR Cup Series playoffs begin with the Round of 16 at the Cook Out Southern 500. The race takes place at Darlington Raceway in Darlington, South Carolina.

Denny Hamlin, who won Saturday’s qualifying race, is the favorite to to win the race on DraftKings Sportsbook. He is +450 to win.

Behind Hamlin are William Byron (+500), Kyle Larson (+600) and Ryan Blaney (+650).

The 2025 Cook Out Southern 500 will take place on Sunday, Aug. 31 at 6 p.m. ET.

Here are the full odds for each driver on DraftKings Sportsbook.

DriverOddsDenny Hamlin+450William Byron+500Kyle Larson+600Ryan Blaney+650Christopher Bell+700Chase Briscoe+800Tyler Reddick+850Chase Elliott+1400Josh Berry+1600Bubba Wallace+1600Ross Chastain+1600Joey Logano+1800Chris Buescher+2500Brad Keselowski+2800Austin Cindric+3000Kyle Busch+3500Ty Gibbs+4000Erik Jones+5000Alex Bowman+5000Ryan Preece+5000Carson Hocevar+5500Justin Haley+6500Austin Dillon+9000Daniel Suarez+13000Michael McDowell+15000Noah Gragson+17000John Hunter Nemechek+20000AJ Allmendinger+20000Zane Smith+20000Todd Gilliland+20000Shane van Gisbergen+20000Cole Custer+25000Ricky Stenhouse Jr.+25000Cody Ware+40000Ty Dillon+50000Derek Kraus+80000Riley Herbst+80000