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Yanquiel Fernandez and the Colorado Rockies take the field on Friday at PETCO Park against JP Sears, who is starting for the San Diego Padres. First pitch will be at 9:40 p.m. ET for the first game of a four-game series. The favored Padres have -308 moneyline odds against the underdog Rockies, who are listed at +247. San Diego is favored on the run line (-1.5 with -145 odds). The game’s over/under has been set at 8 runs.
Check out everything you need from a betting perspective on the Padres-Rockies game, regarding the run line, moneyline and total, plus expert picks.
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Padres vs. Rockies Highlights | MLB on FOX 
Check out the best highlights between the San Diego Padres and Colorado Rockies.
Padres vs. Rockies Game Information & OddsWhen: Friday, September 12, 2025 at 9:40 p.m. ETWhere: PETCO Park in San Diego, CaliforniaHow to watch on TV: SDPA and COLR Favorite Favorite Moneyline Underdog Moneyline Total Over Total Odds Under Total Odds Run Line Favorite Run Line Odds Underdog Run Line Odds Padres -308 +247 8 -106 -114 -1.5 -145 +120 Padres vs. Rockies PredictionScore Prediction: Padres 6, Rockies 4Total Prediction: Over 8 runsWin Probabilities: Padres 62%, Rockies 38%Padres vs. Rockies Betting InsightsThe Padres have won 47, or 58%, of the 81 games they’ve played as favorites this season.San Diego has played as favorites of -308 or more once this season and lost that game.The Padres have a 75.5% chance to win this game based on the implied probability of the moneyline.The Rockies have been victorious in 39, or 27.5%, of the 142 contests they have been chosen as underdogs in this season.Colorado has a mark of 4-20 in contests where oddsmakers favor it by +247 or worse on the moneyline.The moneyline set for this matchup implies the Rockies have a 28.8% chance of walking away with the win.Padres Recent Betting PerformanceThe Padres were the moneyline favorite in nine of their last 10 games, and they finished 3-6 in those matchups.In their last 10 outings, the Padres and their opponents combined to go over the run total three times (all 10 of the games had set totals).The Padres have put together a 2-8-0 record against the spread over their past 10 games.Padres Recent Stats Stat Avg/Total Record 3-7 Runs Per Game 3.7 HR 9 ERA 4.25 K/9 10.4 Padres Player InsightsFernando Tatis Jr. is batting .262 with 27 doubles, two triples, 21 home runs and 84 walks.Among all hitters in the majors, Tatis’ home run total ranks him 60th, and his RBI tally ranks him 92nd.Manny Machado has hit 23 home runs with 84 runs batted in. Both are team-highs.Machado is 49th in homers and 25th in RBI in the majors.Luis Arraez leads the Padres with a team-best batting average of .282.Ramon Laureano’s 23 home runs lead his team.Rockies Recent Betting PerformanceThe Rockies have played as underdogs in 10 of their past 10 games and won two of those contests.In their last 10 games with a total, the Rockies and their opponents are 4-4-2 when it comes to hitting the over.The Rockies have two wins against the spread in their last 10 chances.Rockies Recent Stats Stat Avg/Total Record 2-8 Runs Per Game 3.5 HR 6 ERA 6.52 K/9 7.9 Rockies Player InsightsHunter Goodman leads the lineup with a batting average of .282, while leading the Rockies in home runs, with 30 and runs batted in with 87.Among all batters in the big leagues, Goodman’s home run total is 13th and his RBI tally is 22nd.Mickey Moniak has 17 doubles, eight triples, 19 home runs and 21 walks while hitting .260.Moniak ranks 76th in home runs and 112th in RBI among all hitters in MLB.Jordan Beck has 26 doubles, five triples, 15 home runs and 41 walks while hitting .268.Brenton Doyle is batting .242 with 20 doubles, two triples, 14 home runs and 29 walks.Padres vs. Rockies Highlights | MLB on FOX
Check out the best highlights between the San Diego Padres and Colorado Rockies.
FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.
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