Week 5 of the college football season features a marquee matchup as Ohio State travels west to face Washington at Alaska Airlines Field at Husky Stadium. Kickoff is set for 3:30 p.m. ET, with the Buckeyes entering as 8.5-point favorites. Both teams sit inside the AP Top 25, adding extra weight to a contest that could carry playoff implications down the stretch.

According to Dimers’ predictive model, Ohio State holds a 70% chance of victory after running 10,000 simulations of the game. The Buckeyes’ balanced offense and stout defense have them favored on the road, but Washington is expected to push them, especially with a home-field crowd behind them. Oddsmakers list the total at 53.5 points, with simulations leaning slightly toward the under at 54%.

Dimers’ projected final score is Ohio State 31, Washington 23, suggesting the Huskies could hang around even if the Buckeyes ultimately prevail. The model also identifies value on Washington’s moneyline at +275, despite Ohio State being the more likely winner. With two nationally ranked programs colliding in Seattle, fans can expect a competitive battle with plenty of playoff implications in late September.

Ohio State vs. Washington betting preview

Utilize the interactive widget below to view the latest spread, over/under, and moneyline betting odds and probabilities for the Ohio State-Washington matchup at Alaska Airlines Field at Husky Stadium.

This prediction and best bet for Saturday’s college football matchup between Ohio State and Washington is from Dimers.com, a reliable source for sports betting predictions.

Check out all the important details on today’s game, as well as the best odds sourced from the top sportsbooks in the country.

Game details

The key information you need before the Ohio State vs. Washington college football game.

Teams: Ohio State vs. WashingtonDate: Saturday, September 27, 2025Kickoff: 3:30 p.m. ETLocation: Alaska Airlines Field at Husky StadiumNCAAF rankings: Updated AP Top 25College football news: Check the latest updates from the official NCAA football news siteOdds

Odds for the key markets in the Ohio State-Washington college football battle.

Spread: Ohio State -8.5 (-108), Washington +8.5 (-108)Moneyline: Ohio State -325, Washington +275Total: Over/Under 53.5 (-108/-110)

The odds and lines featured in this article are the best available from selected sports betting sites at the time of publication and are subject to change.

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Expert prediction: Ohio State vs. Washington

Leveraging cutting-edge data analysis and machine learning, the experts at Dimers have performed 10,000 simulations of Saturday’s Ohio State vs. Washington matchup.

According to Dimers’ renowned predictive analytics model, Ohio State is more likely to beat Washington at Alaska Airlines Field at Husky Stadium. This prediction is based on the model giving Ohio State a 70% chance of winning the game.

Elsewhere on the betting board, Dimers predicts that the bookmakers have gotten it right and Ohio State and Washington each have a 50% chance of covering the spread, while the 53.5-point over/under has a 54% chance of staying under.

As always, these predictions and probabilities are accurate at the time of publication but are subject to potential changes.

Ohio State vs. Washington best bet

Our top pick for the Ohio State vs. Washington game on Saturday is to bet on Washington moneyline (+275).

This betting advice is formulated through cutting-edge simulations and valuable betting intelligence, designed to bring you the best possible plays.

While Ohio State is more likely to win the game, according to Dimers, taking Washington moneyline is the best option because of the 2.9% edge identified when comparing Dimers’ data-driven probabilities to the sportsbooks’ odds.

Score prediction for Ohio State vs. Washington

Dimers’ projected final score for the Ohio State vs. Washington game on Saturday has Ohio State winning 31-23.

This expert prediction is based on each team’s average score following 10,000 game simulations, offering a glimpse into the potential outcome.

College football Week 5: Ohio State vs. Washington

Get ready for Saturday’s college football matchup between Ohio State and Washington at Alaska Airlines Field at Husky Stadium, which is scheduled to start at 3:30 p.m. ET. We emphasize that all of the college football best bets and college football predictions on this page are based on 10,000 data-driven simulations of the Ohio State vs. Washington game, and they are correct at the time of publication. They aim to assist you make better decisions when placing bets at online sportsbooks.

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