By Matt Moscona
Alabama, Ole Miss and Oregon came away with massive victories in Week 5.Â
The latter two are idle this week, and Bama faces the surprisingly undefeated Vanderbilt Commadores in Tuscaloosa.
The top matchup this week is Miami at Florida State. Miami put a beatdown on FSU last year (36-14), and, of course, the Noles suffered an ugly defeat at Viriginia on Friday.
Below are the opening lines for Week 6, courtesy of BetOnline.ag.
College football Week 6 lines are subject to change. Here’s the direct link to real-time spreads: https://www.betonline.ag/sportsbook/football/ncaa.
Week 6 College Football Lines
Thursday, October 2, 2025
Sam Houston at New Mexico State (+1.5)
Friday, October 3, 2025
Western Kentucky at Delaware (-2)
Charlotte at South Florida (-27)
New Mexico at San Jose State (-3)
West Virginia at BYU (-19.5)
Colorado State at San Diego State (-6)
Saturday, October 4, 2025
Kentucky at Georgia (-20.5)Â
Iowa State at Cincinnati (PK)
Wisconsin at Michigan (-16)
Boston College at Pittsburgh (-6)
Clemson at North Carolina (+13)
Kansas State at Baylor (-6)
Ohio at Ball State (+16.5)
Wake Forest at Virginia Tech (-4.5)
Oklahoma State at Arizona (-20)
Western Michigan at Massachusetts (+12.5)
Penn State at UCLA (+25.5)
Texas at Florida (+6.5)Â
Vanderbilt at Alabama (-13)Â
Boise State at Notre Dame (-17.5)
Washington at Maryland (+4)
UL Monroe at Northwestern (-12.5)
Oregon State at Appalachian State (+2.5)
Virginia at Louisville (-6)
Florida International at UConn (-10)
James Madison at Georgia State (+20.5)
Central Michigan at Akron (+6.5)
Eastern Michigan at Buffalo (-9)
Miami (OH) at Northern Illinois (+3.5)
Kent State at Oklahoma (-45)
Michigan State at Nebraska (-11)
Texas State at Arkansas State (+11)
Coastal Carolina at Old Dominion (-17.5)
Texas Tech at Houston (+10.5)
South Alabama at Troy (-3)
Florida Atlantic at Rice (-4)
Minnesota at Ohio State (-24.5)
Miami at Florida State (+4.5)
Mississippi State at Texas A&M (-14)Â
Duke at California (+2.5)
Nevada at Fresno State (-13.5)