NFL Week 5 kicks off Thursday night, as the Rams host the 49ers.

Here are the lines for every Week 5 matchup at DraftKings Sportsbook as of Sept. 29.

(All times ET)

2025 NFL Week 5 Odds

THURSDAY, OCT. 2

49ERS @ RAMS

Spread: Rams -3
Moneyline: Rams -180, 49ers +150
Total O/U: 47.5

SUNDAY, OCT. 5

VIKINGS @ BROWNS

Spread: Vikings -4.5
Moneyline: Vikings -218, Browns +180
Total O/U: 37.5

BRONCOS @ EAGLES

Spread: Eagles -5.5
Moneyline: Eagles -238, Broncos +195
Total O/U: 43.5

TEXANS @ RAVENS

Spread: TBD
Moneyline: TBD
Total O/U: TBD

RAIDERS @ COLTS

Spread: Colts -6.5
Moneyline: Colts -298, Raiders +240
Total O/U: 48.5

COWBOYS @ JETS

Spread: Cowboys -1.5
Moneyline: Cowboys -125, Jets +105
Total O/U: 46.5

DOLPHINS @ PANTHERS

Spread: Dolphins -1.5
Moneyline: Dolphins -125, Panthers +105
Total O/U: 46.5

GIANTS @ SAINTS

Spread: Giants -2.5
Moneyline: Giants -135, Saints +114
Total O/U: 42.5

BUCCANEERS @ SEAHAWKS

Spread: Seahawks -2.5
Moneyline: Seahawks -142, Buccaneers +120
Total O/U: 45.5

TITANS @ CARDINALS

Spread: Cardinals -8.5
Moneyline: Cardinals -500, +380
Total O/U: 41.5

LIONS @ BENGALS

Spread: Lions -8.5
Moneyline: Lions -440, Bengals +340
Total O/U: 48.5

COMMANDERS @ CHARGERS

Spread: Chargers -3
Moneyline: Chargers -166, Commanders +140
Total O/U: 47.5

PATRIOTS @ BILLS

Spread: Bills -8.5
Moneyline: Bills -470, Patriots +360
Total O/U: 50.5

MONDAY, OCT. 6

CHIEFS @ JAGUARS

Spread: Chiefs -3
Moneyline: Chiefs -166, Jaguars +140
Total O/U: 45.5

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