The 49ers are expected to alter their starting lineup, as safety Ji’Ayir Brown is scheduled for increased playing time, a source told NBC Sports Bay Area.
Brown is likely to start alongside rookie safety Marques Sigle against the Buccaneers, the source said.
Mustapha likely will be mixed into the action on defense, as the 49ers on Saturday moved him to their 53-man roster. He spent the first five weeks of the season on the physically unable to perform list. Mustapha is returning to action after undergoing surgery in January to repair a detached graft from a previous ACL surgery in his right knee.
Veteran safety Jason Pinnock, who started the first five games of the season, will see a reduction in playing time. Pinnock still could see action in certain defensive packages.