Parkinson made six changes to the side that started the 2-1 loss to Norwich three days earlier for the visit of Leicester, who had lost three successive away Championship games before their trip to north Wales.
Ryan Longman, Matty James, Cacace, Ollie Rathbone, O’Brien and top scorer Kieffer Moore were all drafted in, offering evidence of the strength in depth Parkinson has at his disposal as his injury worries continue to ease.
Wrexham sit just two points outside the top six and, despite dropping two points in the final stages, actually rose to ninth in the table as a result of the Leicester draw.
They return to action on Saturday (15:00 GMT) against a Queens Park Rangers side who were comfortable 3-1 winners ar Stok Cae Ras in September.
But the Red Dragons have grown and evolved significantly as the sides prepare to lock horns again at Loftus Road.
The QPR loss was Wrexham’s third league defeat in five matches at the outset of the campaign, with their return of four points from a possible 15 during that period coming at a rate of 0.6 points per game.
In the 23 league matches since, Wrexham have taken 37 of the 69 points available to them, giving them a drastically improved return of 1.6 points per game over that period.