April 21, 2026Updated 11:13 am EDT
Isaac Paredes leads the Houston Astros into a matchup against the Cleveland Guardians, after his two-homer showing in a 9-2 victory over the Guardians, beginning at 6:10 p.m. ET on Tuesday. Parker Messick (3-0, 1.05 ERA) will start for the Guardians, who are 13-11 this season and first in the AL Central. Ryan Weiss (0-2, 6.75 ERA) is expected to start for the Astros, who are 9-15 and fifth in the AL West.
How to watch Houston Astros vs. Cleveland GuardiansAstros vs. Guardians odds
Injury reportsGuardians
Gabriel Arias: 10 Day IL (Hamstring), Andrew Walters: 15 Day IL (Lat)
Astros
Joey Loperfido: 10 Day IL (Quadricep), Jake Meyers: 10 Day IL (Oblique), Jeremy Pena: 10 Day IL (Knee), Nick Allen: 10 Day IL (Back), Zach Dezenzo: 10 Day IL (Elbow), Hunter Brown: 15 Day IL (Shoulder), Nate Pearson: 15 Day IL (Elbow), Cody Bolton: 15 Day IL (Back), Bennett Sousa: 15 Day IL (Oblique), Tatsuya Imai: 15 Day IL (Arm), Hayden Wesneski: 60 Day IL (Elbow), Ronel Blanco: 60 Day IL (Elbow), Brandon Walter: 60 Day IL (Elbow), Cristian Javier: 60 Day IL (Shoulder), Josh Hader: 60 Day IL (Biceps), Taylor Trammell: day-to-day (Groin)
Stats to know
Cleveland’s Jose Ramirez is slashing .230/.356/.494 this season with six home runs (15th in MLB), 12 RBIs and an OPS of .850. He has a 13.5% strikeout rate and a 16.3% walk rate in 104 plate appearances, and he has scored 16 total runs. Ramirez has recorded 10 steals on 10 attempts.
In 85 plate appearances, Chase DeLauter has hit five long balls, tallied 12 RBIs and scored 11 runs. He is batting .219/.318/.493 and has posted a 12.9% strikeout rate and a 12.9% walk rate.
Yordan Alvarez has hit 10 home runs this season, which ranks 1st in MLB. He has also tallied 21 RBIs (1st in MLB) and has scored 19 runs. In 109 plate appearances, he has recorded a .326 BA, .459 OBP and .756 SLG with a 17.4% walk rate and a 10.1% strikeout rate.
In 98 plate appearances, Christian Walker has hit five long balls, tallied 18 RBIs (11th in MLB) and scored 16 runs. He is batting .274/.367/.536 and has posted a 17.3% strikeout rate and a 12.2% walk rate.
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Photo: Jamie Squire, Ishika Samant, Scott Taetsch, Alika Jenner / Getty Images
Apr 21, 2026
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