Sunday Night Football features a primetime clash between the Buffalo Bills and New England Patriots at Highmark Stadium in Upstate New York. The Sunday Night Football NFL DFS player pool is headlined by Josh Allen, James Cook, Khalil Shakir, Drake Maye, and Stefon Diggs. All five players are expected to be among the most popular NFL DFS picks for SNF. Should you build your NFL DFS stacks and NFL DFS lineups around Allen and Cook? Or would it make sense to target Maye and Diggs?

Other names to keep an eye on in the SNF DFS player pool include Keon Coleman, Dalton Kincaid, and Rhamondre Stevenson. Should any of them be included in your Patriots vs. Bills DFS picks and NFL DFS lineups? Before locking in any NFL DFS picks for Bills vs. Patriots on sites like DraftKings and FanDuel for Sunday Night Football, be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure. 

New users can also target the latest Underdog promo code, which may include a play $5, get $100 offer:

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him is way up.

Now, McClure has turned his attention to Sunday Night Football and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine. 

New players can get $50 in Pick6 credits at DraftKings when they play $5: 

Top NFL DFS picks for Patriots vs. Bills

One of McClure’s top NFL DFS picks for Patriots vs. Bills is Buffalo quarterback Josh Allen. The former Wyoming standout continues to cement his status as one of the premier players of his generation. In 2024, Allen threw for 3,731 yards and 28 touchdowns against just six interceptions while rushing for 531 yards and 12 scores in 17 games, earning the NFL Most Valuable Player award, along with second-team All-Pro and Pro Bowl honors.

Through the first four games of the 2025 season, Allen has thrown for 964 yards, seven touchdowns, and one interception, while completing over 70% of his passes and posting a passer rating of 109.7. Over his career, Allen has become known for his powerful arm, athleticism, and ability to make plays both in and out of the pocket. See who else to roster here.

Part of McClure’s optimal NFL DFS strategy also includes rostering Buffalo running back James Cook. The former Georgia standout delivered a breakout 2024 campaign, carrying the ball 207 times for 1,009 yards and reaching the end zone 16 times, while also contributing as a receiver with 258 yards through the air. He earned his second Pro Bowl nod that season and tied a franchise record for rushing touchdowns in a single season.

In 2025, Cook has totaled 75 carries for 401 rushing yards, scored five rushing touchdowns, and added 89 receiving yards, ranking among the league leaders in both total yardage and scoring. Over his NFL career to date, Cook has shown rare versatility and explosiveness, accumulating over 3,000 rushing yards, more than 900 receiving yards, and more than 30 total touchdowns. See who else to roster here.

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How to set NFL DFS lineups for Bills vs. Patriots

McClure is targeting another undervalued player who could explode for huge numbers on Sunday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure’s NFL DFS picks, at SportsLine.

So who is Mike McClure including in his optimal NFL DFS lineups for Sunday Night Football, and which under-the-radar player offers huge value? Visit SportsLine now to see optimal NFL DFS picks, NFL DFS rankings, NFL DFS advice and NFL DFS stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.Â