A genetic map of human metabolism across the allele frequency spectrum
Study design The UKB is a prospective cohort study from the UK that contains more than 500,000 volunteers…
Exploring the genetic basis of heterosis in eucalypt growth based on transcriptome analysis | BMC Genomics
Preparation of preliminary data In all samples, the proportion of clean reads was higher than 99.5% (Table S2),…
Mapping genes for resilient dairy cows by means of across-breed genome-wide association analysis | BMC Genomics
Data processing and evaluation as well as statistical analyses were performed in software R 4.2.1 [16]. Genotype preparation,…
Limited overlap between genetic effects on disease susceptibility and disease survival
Ethics statement This study was conducted in compliance with the relevant ethical guidelines and approved by the appropriate…
A clinical milestone for CRISPR in sickle-cell disease
The haemoglobinopathies transfusion-dependent β-thalassemia (TDT) and sickle-cell disease (SCD) are two globally prevalent and severe monogenic blood disorders.…
Advances in haplotype phasing and genotype imputation
Voight, B. F., Kudaravalli, S., Wen, X. & Pritchard, J. K. A map of recent positive selection in…
Rapid epigenomic classification of acute leukemia
A comprehensive DNA methylation reference of acute leukemia We curated a comprehensive DNA methylation-based reference cohort from published…
A genomic view of Earth’s biomes
Giovannoni, S., Britschgi, T., Moyer, C. & Field, K. Genetic diversity in Sargasso sea bacterioplankton. Nature 345, 60–63…
Is enhancer-driven gene regulation all wrapped up?
Symmons, O. et al. The Shh topological domain facilitates the action of remote enhancers by reducing the effects…
Regulatory genome annotation | Nature Reviews Genetics
Gerstein, M. B. et al. Architecture of the human regulatory network derived from ENCODE data. Nature 489, 91–100…
Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects
Abul-Husn, N. S. & Kenny, E. E. Personalized medicine and the power of electronic health records. Cell 177,…
Non-CG DNA methylation in animal genomes
Schubeler, D. Function and information content of DNA methylation. Nature 517, 321–326 (2015). Article CAS PubMed Google Scholar …