Chromatix: a differentiable, GPU-accelerated wave-optics library
Design and implementation The design of Chromatix is strongly inspired by current deep learning frameworks. Here we detail…
Why a synthetic human genome is still worth building
Ten years ago, when I was a first-year graduate student, my PhD adviser smuggled me into a private…
Genetic survey exposes flaws in widely used mouse models
C57BL/6 mice, such as the one pictured here, are commonly used in animal research. Credit: Dani Maver/Alamy Half…
Genomic approaches for understanding the evolution of the human brain
Nurk, S. et al. The complete sequence of a human genome. Science 376, 44–53 (2022). Article PubMed PubMed…
Can a mouse be cloned indefinitely? Decades-long experiment has answers
Scientists harvested eggs from 25th-generation cloned mice and fertilized the eggs, which grew into these early-stage embryos. Credit:…
High-throughput phenomics of global ant biodiversity
Meineke, E. K., Davies, T. J., Daru, B. H. & Davis, C. C. Biological collections for understanding biodiversity…
How do genetic association studies rank genes?
RESEARCH BRIEFINGS 19 November 2025 Genome-wide association studies and rare-variant burden tests are the two main tools for…
MSnLib: efficient generation of open multi-stage fragmentation mass spectral libraries
Materials All solvents used were of LC–MS grade. Methanol, acetonitrile, water and formic acid were obtained from Thermo…
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
Animals All mice were maintained according to the National Institutes of Health guidelines and all procedures used in…
Genetic findings of children with congenital heart diseases using chromosomal microarray and trio-based whole exome sequencing
We utilized chromosomal microarray analysis (CMA) and whole exome sequencing (WES) to investigate the prevalence of clinically relevant…