Pancreatic-targeted lipid nanoparticles based on organ capsule filtration
GBD 2021 Diabetes Collaborators. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of…
Shape-conformal porous frameworks for full coverage of neural organoids and high-resolution electrophysiology
Inverse design strategies Inverse design used an AGA to determine 2D microlattice patterns, defined by spatially varying triangular…
Bioresorbable RFID capsule for assessing medication adherence
Brown, M. T. & Bussell, J. K. Medication adherence: WHO Cares? Mayo Clin. Proc. 86, 304–314 (2011). Article …
A multimodal sleep foundation model for disease prediction
Dataset and preprocessing Our dataset includes PSG recordings from four different sites: SSC, BioSerenity, MESA20,21 and MROS20,22, with…
Slipknot-gauged mechanical transmission and robotic operation
Fabrication of the slipknot All experiments were conducted at room temperature (21 °C). The loading rate was set at…
A skin-permeable polymer for non-invasive transdermal insulin delivery
Cell lines and animals The HaCat, mouse hepatoma (AML-12), mouse embryonic fibroblast (3T3-L1) and mouse skeletal muscle (MSMC)…
A probabilistic histological atlas of the human brain for MRI segmentation
Brain specimens Hemispheres from five individuals (including half of the cerebrum, cerebellum and brainstem), were used in this…
A “Masterpiece” – For the First Time, Scientists Keep a Mammalian Cochlea Alive Outside the Body
In his final breakthrough, A. James Hudspeth’s team sustained a living sliver of mammalian cochlea ex vivo and…
High-density soft bioelectronic fibres for multimodal sensing and stimulation
Canales, A., Park, S., Kilias, A. & Anikeeva, P. Multifunctional fibers as tools for neuroscience and neuroengineering. Acc.…
Forget smartwatches, scientists teach WiFi to monitor heartbeats
Your WiFi can now do more than stream movies; it can sense the beat of your heart. Engineers…
An efficient machine-learning framework for predicting protein post-translational modification sites
Hyperparameter optimization The LightGBM classifier for Khib site prediction requires systematic hyperparameter optimization to achieve optimal predictive performance.…
In vitro evidence of bubble-induced acoustic softening and Sanal flow choking in cardiovascular decompression
This pilot in vitro study explored how decompression-induced microbubble nucleation and acoustic softening contribute to flow instability and…