Real-world, digital-first delivery of GLP-1 receptor agonist therapy in women
Study population Between 27 November 2024 and 31 January 2025, adult women (female sex at birth) were recruited…
Probing the many benefits of GLP-1 receptor agonists
RESEARCH HIGHLIGHT 05 October 2026 Glucagon-like peptide 1 (GLP-1) receptor agonists are approved for the treatment of type…
Performance and safety of a multi-cancer early detection test: the PATHFINDER 2 study
Ethical approval and consent This study was performed in accordance with the Declaration of Helsinki. All study procedures…
The shared evolutionary capacities of plasmids and extrachromosomal DNA
Kuzminov, A. Bacterial nucleoid is a riddle wrapped in a mystery inside an enigma. J. Bacteriol. 206, e0021123…
Cohesin prevents local mixing of condensed euchromatic domains in living human cells
All experiments complied with relevant ethical regulations. This study used established human cell lines and involved no human…
A scoping review on the mental health harms of LLM-based chatbots
Weizenbaum, J. ELIZA—a computer program for the study of natural language communication between man and machine. Commun. ACM…
Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial
This study of psilocybin assisted-therapy for TRD—to our knowledge, the first RCT in this population to assess feasibility…
Fixed-dose inotuzumab ozogamicin (INO) combined with Vincristine and Prednisone (VP) regimen as induction therapy for newly diagnosed B-cell acute lymphocytic leukemia (B-ALL): a multi-center, open-label, single-arm, prospective clinical study
Adult B-ALL exhibits significant heterogeneity and poor prognosis compared with the pediatric population. While the complete remission (CR)…
SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry
Bostick, M. et al. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317, 1760–1764…
Pervasive interactions between exposures and polygenic risk can inform more effective clinical and behavioral interventions
Lewis, A. C. F. et al. Managing differential performance of polygenic risk scores across groups: real-world experience of…
Small language models in medicine
These authors contributed equally: Yiming Qin, Tao Yan, Matthew Yu Heng Wong. School of Clinical Medicine, Beijing Tsinghua…
Health system learning enables generalist neuroimaging models
Health system learning We define ‘health system learning’ as learning directly from uncurated data generated during routine clinical…