A scoping review on the mental health harms of LLM-based chatbots
Weizenbaum, J. ELIZA—a computer program for the study of natural language communication between man and machine. Commun. ACM…
Psilocybin-assisted therapy for treatment-resistant major depressive disorder in a public healthcare setting: a randomized controlled trial
This study of psilocybin assisted-therapy for TRD—to our knowledge, the first RCT in this population to assess feasibility…
Fixed-dose inotuzumab ozogamicin (INO) combined with Vincristine and Prednisone (VP) regimen as induction therapy for newly diagnosed B-cell acute lymphocytic leukemia (B-ALL): a multi-center, open-label, single-arm, prospective clinical study
Adult B-ALL exhibits significant heterogeneity and poor prognosis compared with the pediatric population. While the complete remission (CR)…
SUMOylation enhances DNMT1 function to repress mega-intergenic RNAs and viral mimicry
Bostick, M. et al. UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317, 1760–1764…
Pervasive interactions between exposures and polygenic risk can inform more effective clinical and behavioral interventions
Lewis, A. C. F. et al. Managing differential performance of polygenic risk scores across groups: real-world experience of…
Small language models in medicine
These authors contributed equally: Yiming Qin, Tao Yan, Matthew Yu Heng Wong. School of Clinical Medicine, Beijing Tsinghua…
Health system learning enables generalist neuroimaging models
Health system learning We define ‘health system learning’ as learning directly from uncurated data generated during routine clinical…
Identifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing
Adapting prime editing for mammalian histone mutagenesis Mouse canonical histone H3 is encoded by nine H3.1 and three…
Identifying and reprogramming softness-driven cancer stem-like cells overcomes CAR-T cell resistance in solid tumours
Liu, Q., Luo, Q., Ju, Y. & Song, G. Role of the mechanical microenvironment in cancer development and…
Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modelling
Derivation of retinal endothelial cells from human induced pluripotent stem cells via the Norrin–Fz4 axis To obtain RECs…
Off‑the‑shelf, engineered non-living stem cell strategy for advancing cellular therapies
Bashor, C. J., Hilton, I. B., Bandukwala, H., Smith, D. M. & Veiseh, O. Engineering the next generation…
Large reasoning models as thinking machines for medicine
Jaech, A. et al. OpenAI o1 system card. Preprint at https://arxiv.org/abs/2412.16720 (2024). Guo, D. et al. DeepSeek-R1 incentivizes…