Identifying and reprogramming softness-driven cancer stem-like cells overcomes CAR-T cell resistance in solid tumours
Liu, Q., Luo, Q., Ju, Y. & Song, G. Role of the mechanical microenvironment in cancer development and…
Dual tumour–myeloid targeting of glioblastoma with GPNMB CAR-T cells
Cell lines and patient-derived GSC cultures Human GBM samples were obtained from patients who provided written informed consent…
The body’s most mysterious organ may play a key role in longevity and cancer
For decades, a mysterious, two-lobed organ nestled behind the breastbone has been overlooked by most physicians, thought to…
Prospective evaluation of genomics-guided off-label treatment
Over the past nine years, DRUP provided opportunities for off-label treatment to more than 1,600 patients with advanced…
Thymic health and immunotherapy outcomes in patients with cancer
In this study we provide evidence for the clinical relevance of thymic health in immuno-oncology. We found that…
Fecal microbiota transplantation plus immunotherapy in non-small cell lung cancer and melanoma: the phase 2 FMT-LUMINate trial
Study participants and clinical trial design The FMT-LUMINate trial (NCT04951583) is a multicenter, open-label, phase 2 trial that…
The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction
Mice Male and female mice were used for the study. CD45.1+ OT-I or P14 TCR-transgenic mice were housed…
Pan-Cancer Immunotherapy Avoids Healthy Tissue by Targeting Glycans
Bispecific antibodies and chimeric antigen receptor (CAR) T cells demonstrate potent cancer immunotherapy in clinical use, yet most…
Pan-Cancer Immunotherapy Avoids Healthy Tissue by Targeting Glycans
Bispecific antibodies and chimeric antigen receptor (CAR) T cells demonstrate potent cancer immunotherapy in clinical use, yet most…
Experimental Neuroblastoma Therapy Overcomes Resistance in Mice
Credit: Nemes Laszlo/Getty Images Researchers at St. Jude Children’s Research Hospital have reported encouraging results for a novel…
A 100% effective cancer vaccine? Russia’s Enteromix achieves success in trials; Here’s the full report you need to read
A vaccine that could change the way we fight cancer is making headlines. Russia’s Enteromix has reportedly achieved…