Ageing promotes metastasis via activation of the integrated stress response
Mice and in vivo studies KrasLSL-G12D/+Trp53flox/flox mice (designated as KP)60 were maintained on a mixed C57BL/6-129/Sv genetic background.…
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy
Mouse studies Wild-type C57BL/6 male mice (6–8 weeks of age) were purchased from BIKAI. Nlrx1−/− mice were purchased from Cyagen.…
Lymph node environment drives FSP1 targetability in metastasizing melanoma
Cell lines B16-F0 (ATCC; CRL-6322) and its LN metastatic derivatives: NBF0-LN1-18IL, NBF0-LN7-1112AR, NBF0-LN7-1120BL, NBF0-LN7-1134BL, NBF0-LN8-1194BR, NBF0-LN8-1198AR, NBF0-LN8-1205BL, NBF0-LN9-1315BL…
Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD
Cell culture and cell lines The following CRC cell lines were obtained from the American Type Culture Collection…