Osteoclasts intercept meningeal lymphatic paths for dural metastasis
Laigle-Donadey, F. et al. Dural metastases. J. Neurooncol. 75, 57–61 (2005). Article PubMed Google Scholar Nayak, L. et…
Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC
Kow, A. W. C. Hepatic metastasis from colorectal cancer. J. Gastrointest. Oncol. 10, 1274–1298 (2019). Article PubMed PubMed…
Accurate, scalable and cross-platform cell identification for high-resolution spatial transcriptomics
Stahl, P. L. et al. Visualization and analysis of gene expression in tissue sections by spatial transcriptomics. Science…
Non-invasive profiling of the tumour microenvironment with spatial ecotypes
Human subjects All human samples included in this study were collected with informed consent for research use and…
Emergence of oncofetal plasticity is ubiquitous in early colorectal cancers
Patients This study was approved by the University Medical Centre (UMC) Utrecht ethical committee, carried out in accordance…
The ubiquitin ligase KLHL6 drives resistance to CD8+ T cell dysfunction
Mice Male and female mice were used for the study. CD45.1+ OT-I or P14 TCR-transgenic mice were housed…
Lymph node environment drives FSP1 targetability in metastasizing melanoma
Cell lines B16-F0 (ATCC; CRL-6322) and its LN metastatic derivatives: NBF0-LN1-18IL, NBF0-LN7-1112AR, NBF0-LN7-1120BL, NBF0-LN7-1134BL, NBF0-LN8-1194BR, NBF0-LN8-1198AR, NBF0-LN8-1205BL, NBF0-LN9-1315BL…
Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer
de Magalhaes, J. P. How ageing processes influence cancer. Nat. Rev. Cancer 13, 357–365 (2013). Article PubMed Google…
Mechanical confinement governs phenotypic plasticity in melanoma
Zebrafish husbandry Stable transgenic zebrafish lines were kept at 28.5 °C in a dedicated aquatics facility with a 14 h…
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy
Clinical samples and cohorts Supplementary Table 10 summarizes the different clinical cohorts used in this Article, and presents…