Conformational diversity and fully opening mechanism of native NMDA receptor
Traynelis, S. F. et al. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol. Rev. 62, 405–496 (2010).…
Targeting mGlyR with nanobodies for depression
Animals All animal experiments were approved by the Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology…
Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
aSyn expression Escherichia coli strain BL21(DE3) was transformed with pT7-7 aSyn WT vector43 from Addgene, (plasmid 36046) and…
Structural snapshots capture nucleotide release at the μ-opioid receptor
Data reporting No statistical methods were used to predetermine sample size. The experiments were not randomized, and the…
Mechanism of conductance control and neurosteroid binding in NMDA receptors
Hille, B. Ion Channels of Excitable Membranes 3rd edn (Sinauer, 2001). Jahr, C. E. & Stevens, C. F.…
Helicase-mediated mechanism of SSU processome maturation and disassembly
Generation of endogenously tagged DHR1, KRE33, UTP7 and UTP14 strains Assembly intermediates of the S. cerevisiae SSU processomes…