Longevity is Carried In the Lysosome
Changes in Caenorhabditis elegans lysosome metabolism can be carried through generations via inherited histone modifications. A team of…
Non-CG DNA methylation in animal genomes
Schubeler, D. Function and information content of DNA methylation. Nature 517, 321–326 (2015). Article CAS PubMed Google Scholar …
Spatial joint profiling of DNA methylome and transcriptome in tissues
Tissue slide preparation Mouse C57 embryo sagittal frozen sections (MF-104-11-C57 and MF-104-13-C57) were purchased from Zyagen. Freshly collected…
Chromatin dynamics of a large-sized genome provides insights into polyphenism and X0 dosage compensation of locusts
Chromosome-level assembly of the migratory locust We conducted genome sequencing on an adult female locust with a heterozygosity…
Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivity
BRG1 binding exhibits a linear response to its dosage In mES cells, Brg1 encodes the major catalytic subunit…
Thymic epithelial cells amplify epigenetic noise to promote immune tolerance
Mice The mice used in this study were housed in pathogen-free facilities at the University of Chicago and…
Tracing the evolution of single-cell 3D genomes in Kras-driven cancers
Ethics Statement All animal studies were approved by the Institutional Animal Care and Use Committee of Yale University.…
Establishment of chromatin architecture interplays with embryo hypertranscription
Hug, C. B. & Vaquerizas, J. M. The birth of the 3D genome during early embryonic development. Trends…