Clarifying Uncertain Genetic Tests in Cancer Treatment
Cancer treatment is becoming more personalised. By considering a patient’s unique genetic and molecular profile, along with their…
The evolution of hominin bipedalism in two steps
Sample collection Human developmental stages E45–E72 were obtained from first-trimester termination procedures conducted at the Birth Defects Research…
CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes
Animals All mice were maintained according to the National Institutes of Health guidelines and all procedures used in…
Adaptive genetics reveals constraints on protein structure/function by evolving E. coli under constant nutrient limitation | BMC Biology
Experimental design The design of our evolution experiments has been described in detail previously [25]. Briefly, using Davis…
Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states
Regev, A. et al. The human cell atlas. eLife 6, e27041 (2017). PubMed PubMed Central Google Scholar Karlsson,…
Methods and applications of in vivo CRISPR screening
Auton, A. et al. A global reference for human genetic variation. Nature 526, 68–74 (2015). Google Scholar GarcÃa-GarcÃa,…
Multiplexed assays of variant effect for clinical variant interpretation
Chen, E. et al. Rates and classification of variants of uncertain significance in hereditary disease genetic testing. JAMA…