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Browsing Tag

Gene Expression

30 posts
GGenetics
Genotyping sequence-resolved copy number variation using pangenomes reveals paralog-specific global diversity and expression divergence of duplicated genes
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Genotyping sequence-resolved copy number variation using pangenomes reveals paralog-specific global diversity and expression divergence of duplicated genes

  • October 19, 2025
Overview of the genotyping method We represent variation as haplotype segments that are short enough to minimize disruption…
GGenetics
The LMSz method - an automatable scalable approach to constructing gene-specific growth charts in rare disorders
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The LMSz method – an automatable scalable approach to constructing gene-specific growth charts in rare disorders

  • October 12, 2025
We have developed a method for producing gene-specific z-score centile charts and growth charts based on small datasets…
GGenetics
Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation
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Systema: a framework for evaluating genetic perturbation response prediction beyond systematic variation

  • October 11, 2025
Nonparametric baselines We design two nonparametric baselines that we refer to as perturbed mean and matching mean. Perturbed…
GGenetics
Brain cells beat AI in learning speed and efficiency
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Largest study of African American brain tissue reveals key Alzheimer gene activity

  • October 8, 2025
The prevalence of Alzheimer disease (AD) is approximately two times higher in African Americans (AA) compared to White/European-ancestry…
GGenetics
Further phenotypical delineation of DLG3-related neurodevelopmental disorders
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Further phenotypical delineation of DLG3-related neurodevelopmental disorders

  • September 22, 2025
Elias GM, Elias LAB, Apostolides PF, Kriegstein AR, Nicoll RA. Differential trafficking of AMPA and NMDA receptors by…
GGenetics
Diversity challenges and reconciles genetics in facioscapulohumeral muscular dystrophy
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Diversity challenges and reconciles genetics in facioscapulohumeral muscular dystrophy

  • September 16, 2025
Wang LH, Tawil R. Facioscapulohumeral dystrophy. Curr Neurol Neurosci Rep. 2016;16:66. Article  PubMed  Google Scholar  Mul K, Lassche…
GGenetics
Genetic variants affecting RNA stability influence complex traits and disease risk
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Genetic variants affecting RNA stability influence complex traits and disease risk

  • September 12, 2025
Ethics This research study did not require approval from any specific ethics board/committee. CNV removal We obtained absolute…
GGenetics
AI Model Finds Gene Targets and Drug Combos to Reprogram Diseased Cells
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AI Model Finds Gene Targets and Drug Combos to Reprogram Diseased Cells

  • September 10, 2025
Credit: FlashMovie/Getty Images Traditional drug discovery has often followed the “one drug, one target” paradigm—developing compounds against individual…
GGenetics
News18
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Expert Explains How Love Heals Body Through DNA, Internet Says, ‘It Can Damage Too’ | Viral News

  • September 7, 2025
Last Updated:September 07, 2025, 06:30 IST Dr Niraj Rai explained how love doesn’t just make you feel good,…
GGenetics
New method advances RNA velocity analysis with spatial and multi batch integration
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New method advances RNA velocity analysis with spatial and multi batch integration

  • September 6, 2025
Essentially all cells in an organism’s body have the same genetic blueprint, or genome, but the set of…
GGenetics
Clinical exome sequencing efficacy and phenotypic expansions involving non-isolated congenital anomalies of kidney and urinary tract (CAKUT+)
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Clinical exome sequencing efficacy and phenotypic expansions involving non-isolated congenital anomalies of kidney and urinary tract (CAKUT+)

  • September 6, 2025
Capone VP, Morello W, Taroni F, Montini G. Genetics of congenital anomalies of the kidney and urinary tract:…
GGenetics
Molecular genetics and therapeutic development for GNE myopathy
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Molecular genetics and therapeutic development for GNE myopathy

  • September 5, 2025
Yoshioka W, Noguchi S, Mori-Yoshimura M, Nishino I. Advances in understanding of the natural history, mechanism, extra-muscular manifestations…
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